Savings guide
How to Save on Prilosec OTC (Omeprazole) 20 mg
Generic Omeprazole averages $9.50 vs brand Prilosec OTC at $24.99 — a 62% difference.
Current lowest price
The lowest cash price we track for Prilosec OTC 20 mg is about $9.50. Prices update as pharmacies change them — see the full live table below.
Compare live Prilosec OTC prices →Generic vs brand
The FDA requires generic medications to demonstrate bioequivalence, meaning the same active ingredient, strength, dosage form, and route of administration as the brand-name product. A generic version of Omeprazole works the same way in the body as brand Prilosec OTC.
Because generics don't carry the original research and marketing costs, they usually cost far less while meeting the same FDA quality, strength, and purity standards. Read our generic vs. brand explainer →
Cheapest pharmacies for Prilosec OTC
Compare live prices on the Prilosec OTC page to see the cheapest pharmacies near you.
Steps to save on Prilosec OTC
1. Compare cash prices
Compare Prilosec OTC cash prices across every US pharmacy before you fill — the same drug can cost several times more at one counter than another.
2. Check for a generic
Ask your prescriber or pharmacist about generic Omeprazole, which is usually far cheaper than brand Prilosec OTC and is FDA-rated therapeutically equivalent.
3. Apply a pharmacy coupon
Use a free discount coupon (such as GoodRx) at the pharmacy counter. Coupons and insurance cannot be combined, so compare the cash-coupon price against your copay.
4. Ask about patient assistance
Ask the manufacturer and nonprofit foundations whether a patient-assistance or copay program covers this medication if you qualify.
5. Try mail-order
Mail-order pharmacies like Mark Cuban Cost Plus often price 90-day generic supplies below retail. Confirm the drug is in their catalog first.
FAQ
How can I save money on Prilosec OTC?
Compare cash prices across pharmacies, ask about generic Omeprazole, use a free coupon, and check for a manufacturer assistance program. Prices for the same drug vary widely between pharmacies.
Is there a generic version of Prilosec OTC?
Yes — Omeprazole is available as a generic and is usually much cheaper than brand Prilosec OTC. The FDA requires it to have the same active ingredient, strength, and dosage form.
Does Prilosec OTC have a manufacturer savings program?
We don't have a verified manufacturer savings program on file for Prilosec OTC. Compare pharmacy cash prices and coupons, which anyone can use without enrollment.
Which pharmacy has the cheapest Prilosec OTC?
Cash prices change often. Compare the live price table on this drug's page — Mark Cuban Cost Plus and Costco are frequently cheapest for generics.
Do I need insurance to get these prices?
No. Every price and coupon shown is a cash-pay price that anyone can use without insurance. Compare the cash price against your insurance copay and use whichever is lower.