Savings guide
How to Save on Trikafta (Elexacaftor/Tezacaftor/Ivacaftor) 100mg/50mg/75mg
Current lowest price
The lowest cash price we track for Trikafta 100mg/50mg/75mg is about $0.40. Prices update as pharmacies change them — see the full live table below.
Compare live Trikafta prices →Generic vs brand
The FDA requires generic medications to demonstrate bioequivalence, meaning the same active ingredient, strength, dosage form, and route of administration as the brand-name product. A generic version of Elexacaftor/Tezacaftor/Ivacaftor works the same way in the body as brand Trikafta.
Because generics don't carry the original research and marketing costs, they usually cost far less while meeting the same FDA quality, strength, and purity standards. Read our generic vs. brand explainer →
Manufacturer assistance
Trikafta has an official manufacturer savings program, Vertex GPS. Eligibility rules apply (manufacturer copay cards typically require commercial insurance). Check the official program page for current terms.
Cheapest pharmacies for Trikafta
- Kroger Rx$0.40
Steps to save on Trikafta
1. Compare cash prices
Compare Trikafta cash prices across every US pharmacy before you fill — the same drug can cost several times more at one counter than another.
2. Check for a generic
Ask whether a generic or therapeutic alternative is available — generics are FDA-rated therapeutically equivalent and usually cost far less.
3. Apply a pharmacy coupon
Use a free discount coupon (such as GoodRx) at the pharmacy counter. Coupons and insurance cannot be combined, so compare the cash-coupon price against your copay.
4. Ask about patient assistance
Trikafta has a manufacturer program (Vertex GPS) that may lower or cover your cost if you qualify.
5. Try mail-order
Mail-order pharmacies like Mark Cuban Cost Plus often price 90-day generic supplies below retail. Confirm the drug is in their catalog first.
FAQ
How can I save money on Trikafta?
Compare cash prices across pharmacies, ask about generic Elexacaftor/Tezacaftor/Ivacaftor, use a free coupon, and check for a manufacturer assistance program. Prices for the same drug vary widely between pharmacies.
Is there a generic version of Trikafta?
Trikafta's active ingredient is Elexacaftor/Tezacaftor/Ivacaftor. Ask your pharmacist whether a generic or lower-cost therapeutic alternative is currently available for you.
Does Trikafta have a manufacturer savings program?
Yes. Vertex GPS is the official manufacturer program. Eligibility rules apply — check https://www.vertexgps.com for current terms.
Which pharmacy has the cheapest Trikafta?
Right now Kroger Rx shows one of the lowest cash prices, around $0.40. Mark Cuban Cost Plus and Costco are frequently the cheapest for generics.
Do I need insurance to get these prices?
No. Every price and coupon shown is a cash-pay price that anyone can use without insurance. Compare the cash price against your insurance copay and use whichever is lower.