Gabapentin

What it treats

Neuropathic pain, partial seizures, restless legs syndrome (off-label).

Typical dosing

Titrated from 300 mg/day up to 1800-3600 mg/day in divided doses (dose depends on indication and response). Dose MUST be reduced with impaired kidney function, gabapentin is cleared almost entirely by the kidneys: • CrCl ≥60 mL/min: standard dosing (up to 3600 mg/day in 3 divided doses). • CrCl 30-59 mL/min: reduce total daily dose by about 50% (e.g. 400-1400 mg/day in 2 divided doses). • CrCl 15-29 mL/min: reduce further, about 25% of standard (e.g. 200-700 mg/day, once daily). • CrCl <15 mL/min: 100-300 mg once daily. • Hemodialysis: use a reduced maintenance dose based on CrCl, PLUS a supplemental dose after each dialysis session (dialysis removes gabapentin). Always confirm the exact dose with your prescriber/pharmacist using your current renal function.

Monitoring

Kidney function (CrCl/eGFR) before starting and periodically, since dosing depends on it. Watch for signs of respiratory depression (excess sedation, slow/shallow breathing) especially when combined with opioids or benzodiazepines.

Side effects

Drowsiness, dizziness, peripheral edema, weight gain, fatigue, coordination problems. Serious: respiratory depression (see warning above), suicidal thoughts (small increased risk across anticonvulsants), severe allergic reaction (DRESS syndrome, rash, fever, swollen lymph nodes).

Interactions to know

Antacids reduce absorption, separate by 2 hours. Additive sedation and respiratory depression risk with opioids, benzodiazepines, alcohol, and other CNS depressants, this combination requires caution and, often, dose adjustment or closer monitoring per your prescriber.

Pregnancy & breastfeeding

Limited data, discuss with prescriber.

Frequently asked questions

How much does Gabapentin cost without insurance?

We compare cash prices for Gabapentin live across verified pharmacies on the drug page, the current lowest price is shown there. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.

Is there a generic for Gabapentin?

Yes. Gabapentin is the generic; it is also sold under brand names such as Neurontin. The generic is typically far cheaper than brand and is what our verified cash prices reflect.

Can I use the free BetterBuyRx discount card for Gabapentin?

Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Gabapentin, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.

Why does the price of Gabapentin vary so much between pharmacies?

U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the Anticonvulsant / neuropathic pain agent class). That's why comparing verified prices before you fill can save money.