Ondansetron
Sold as Zofran
Ondansetron blocks serotonin (5-HT3) receptors in the gut and brain to prevent nausea and vomiting. Originally approved for chemotherapy- and surgery-related nausea, it's also widely prescribed off-label for nausea in pregnancy.
As of August 2026, Ondansetron (4 mg) cash prices on BetterBuyRx start at $5.00 across 6 verified sources (lowest at Amazon Pharmacy RxPass). The free BetterBuyRx discount card is compared live on the drug page when a partner network prices this combo. Prices change; confirm at the counter.
What it treats
Prevents nausea and vomiting from chemotherapy, radiation, and surgery. Also used off-label for hyperemesis gravidarum / morning sickness in pregnancy.
Typical dosing
Typical adult dose: 4-8 mg by mouth every 8 hours as needed, or as directed by your prescriber.
Side effects
Common: headache, constipation, tiredness. Serious (rare): QT prolongation (irregular heartbeat), serotonin syndrome when combined with other serotonergic drugs.
Interactions to know
Caution with other drugs that prolong the QT interval, and with other serotonergic medications (e.g. SSRIs, tramadol) due to serotonin syndrome risk.
Pregnancy & breastfeeding
FDA Pregnancy Category B. Widely used off-label for nausea in pregnancy. Some studies suggested a small association with cleft palate in the first trimester; larger studies have not confirmed increased birth defect risk. Discuss with your OB or midwife before use, do not self-prescribe.
Live price snapshot
| Source | Type | Cash price |
|---|---|---|
| Amazon Pharmacy RxPass | program | $5.00 |
| Honeybee Health | pharmacy | $6.00 |
| Mark Cuban Cost Plus | pharmacy | $6.17 |
| Mark Cuban Cost Plus | pharmacy | $6.28 |
| PlanetDrugsDirect | pharmacy | $42.99 |
| RxConnected.com | pharmacy | $76.00 |
Save with the free BetterBuyRx card
The BetterBuyRx discount card is free, no signup, no insurance needed. When a partner network prices Ondansetron, the card price appears live on the drug page with its BIN, PCN, Group, and Member ID. Show the card at the pharmacy counter; it can't be combined with insurance.
Frequently asked questions
- How much does Ondansetron cost without insurance?
- As of the latest check, the lowest verified cash price we've found for Ondansetron is $5.00 at Amazon Pharmacy RxPass, across 6 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.
- Is there a generic for Ondansetron?
- Yes. Ondansetron is the generic; it is also sold under brand names such as Zofran. The generic is typically far cheaper than brand and is what our verified cash prices reflect.
- Can I use the free BetterBuyRx discount card for Ondansetron?
- Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Ondansetron, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.
- Why does the price of Ondansetron vary so much between pharmacies?
- U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the 5-HT3 receptor antagonist (antiemetic) class). That's why comparing verified prices before you fill can save money.
Clinical content reviewed by the BetterBuyRx clinical team.
Educational only. Not medical advice. Always confirm with your prescriber or pharmacist.