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Diabetes

Glucophage

Metformin · 500 mg · tablet · qty 60

Also available in: 500mg · 850mg · 1000mg

Type 2 diabetes blood-sugar control.

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Common uses & information

Glucophage is a brand of Metformin, a diabetes medication supplied as tablet in a 500 mg strength. It is commonly used for type 2 diabetes blood-sugar control.

An FDA-approved generic (Metformin) is available and typically costs less than the brand — compare both cash prices in the table above before you fill.

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Price summary

FormClassBrand avgGeneric avgSavings
tablet 500 mgRx$89.00 — generic is cheaper, see recommendation$4.00Generic recommended96%

Clinical information

Typical dosing

Max dose differs by formulation — do not assume one number: • Immediate-release (IR) — e.g. Glucophage: max 2550 mg/day, given in divided doses (typically 2–3x/day with meals). Usual starting dose 500 mg twice daily, titrated slowly to reduce GI side effects. • Extended-release (XR/ER) — e.g. Glucophage XR, Fortamet, Glumetza: max is generally 2000 mg/day (Glucophage XR label); check the specific product's FDA label, as some ER formulations (e.g. Fortamet) are approved up to 2500 mg/day. Taken once daily, usually with the evening meal.

Monitoring

Kidney function (eGFR) before starting and at least annually (more often if at risk). Metformin is contraindicated at eGFR below 30 mL/min/1.73m² due to lactic-acidosis risk; dose should be reassessed and often reduced at eGFR 30–45. Periodic vitamin B12 levels with long-term use.

Side effects

Common: nausea, diarrhea, gas, metallic taste — usually improves in 1–2 weeks. Rare but serious: lactic acidosis, more likely with kidney impairment, dehydration, or heavy alcohol use. Long-term use can lower vitamin B12 — periodic B12 monitoring is recommended, especially with anemia or neuropathy symptoms.

Interactions to know

Tell your doctor before any imaging study with IV contrast — metformin may need to be held around the procedure. Alcohol increases lactic acidosis risk.

Pregnancy & breastfeeding

Generally considered safe in pregnancy; discuss with your obstetrician.

Clinical content reviewed by the BetterBuyRx clinical team, on 2026-07-07. Read the full wiki entry and sources →

Manufacturer & patient assistance programs

For patient assistance, check NeedyMeds and RxAssist.

FAQ

Is generic Metformin the same as Glucophage?

Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.

How much can I save by choosing the generic?

On average $85.00 per fill (96% off the brand price). Savings vary by pharmacy — see live prices above.

Do I need insurance to get this price?

No. The prices shown on BetterBuyRx are cash prices. Often these beat insurance copays for generics.

How often is this price updated?

At minimum every 72 hours. Many sources refresh every few hours.

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Information for general comparison only. Not medical advice. Confirm with your pharmacist.