Type 2 Diabetes medication prices (2026)
Type 2 diabetes is treated with oral medications (metformin, sulfonylureas, DPP-4 inhibitors, SGLT2 inhibitors) and injectable GLP-1 agonists. Cash prices for older generics like metformin are under $10/month; brand GLP-1s like Ozempic and Mounjaro can exceed $1,000/month without insurance.
All Diabetes medications ranked by cash price
| Brand | Generic | Strength | Generic cash | Brand cash |
|---|---|---|---|---|
| Semglee | Insulin Glargine-yfgn | 100 units/mL | see live | see live |
| Lyumjev | Insulin Lispro-aabc | 100 units/mL | see live | see live |
| Invokana | Canagliflozin | 100 mg | see live | see live |
| DiaBeta | Glyburide | 5 mg | see live | see live |
| Prandin | Repaglinide | 1 mg | see live | see live |
| Nesina | Alogliptin | 25 mg | see live | see live |
| Byetta | Exenatide | 10 mcg/dose | see live | see live |
| Tresiba | Insulin Degludec | 100 units/mL | see live | see live |
| Humulin N | Insulin Isophane | 100 units/mL | see live | see live |
| Humulin R | Insulin Regular | 100 units/mL | see live | see live |
| Adlyxin | Lixisenatide | 20mcg | see live | see live |
| Afrezza | Insulin Human Inhaled | 8 units | see live | $2041.72 |
| Avandia | Rosiglitazone | 4mg | see live | see live |
| Brenzavvy | Bexagliflozin | 20mg | see live | see live |
| Fiasp | Insulin Aspart Ultra Fast | 100 units/mL | see live | $768.97 |
| Glyxambi | Empagliflozin/Linagliptin | 10mg/5mg | see live | $583.77 |
| Humalog Mix 75/25 | Insulin Lispro Protamine 75/25 | 100 units/mL | see live | $259.93 |
| Humalog U-200 | Insulin Lispro U-200 | 200 units/mL | see live | see live |
| Humulin R U-500 | Insulin Regular U-500 | 500 units/mL | see live | $2123.12 |
| Invokamet | Canagliflozin/Metformin | 150mg/500mg | see live | $279.34 |
| Janumet | Sitagliptin/Metformin | 50mg/1000mg | see live | $538.03 |
| Jentadueto | Linagliptin/Metformin | 2.5mg/1000mg | see live | $501.71 |
| Mitiglinide | Mitiglinide | 10mg | see live | see live |
| NovoLog Mix 70/30 | Insulin Aspart Mix 70/30 | 100 units/mL | see live | $229.80 |
| Steglatro | Ertugliflozin | 5mg | see live | $343.57 |
| Symlin | Pramlintide | 1000mcg/mL | see live | $1711.19 |
| Synjardy | Empagliflozin/Metformin | 12.5mg/1000mg | see live | $288.28 |
| Tanzeum | Albiglutide | 30mg | see live | see live |
| Toujeo | Insulin Glargine U-300 | 300 units/mL | see live | $720.84 |
| Tresiba U-200 | Insulin Degludec U-200 | 200 units/mL | see live | see live |
| Tzield | Teplizumab | 2mg/2mL | see live | see live |
| Xigduo XR | Dapagliflozin/Metformin | 10mg/1000mg | see live | $408.22 |
| Glucophage | Metformin | 500 mg | $4.00 | $89.00 |
| Amaryl | Glimepiride | 2 mg | $4.80 | $68.00 |
| Glucotrol | Glipizide | 10 mg | $5.40 | $72.00 |
| Actos | Pioglitazone | 30 mg | $12.40 | $148.00 |
| Actoplus Met | Pioglitazone/Metformin | 15mg/850mg | $14.40 | $572.08 |
| Precose | Acarbose | 50 mg | $24.00 | $128.00 |
| Starlix | Nateglinide | 120mg | $30.56 | $30.56 |
| Lantus | Insulin Glargine | 100 units/mL | $68.00 | $284.00 |
| Levemir | Insulin Detemir | 100 units/mL | $72.00 | $289.00 |
| Humalog | Insulin Lispro | 100 units/mL | $78.50 | $332.00 |
| NovoLog | Insulin Aspart | 100 units/mL | $82.00 | $328.00 |
| Glyset | Miglitol | 50mg | $155.96 | $155.96 |
| Kombiglyze XR | Saxagliptin/Metformin XR | 5mg/1000mg | $159.19 | $343.00 |
| Januvia | Sitagliptin | 100 mg | $289.00 | $612.00 |
| Onglyza | Saxagliptin | 5 mg | $468.00 | $512.00 |
| Farxiga | Dapagliflozin | 10 mg | $592.00 | $612.00 |
| Jardiance | Empagliflozin | 25 mg | $628.00 | $648.00 |
| Victoza | Liraglutide | 1.8 mg/dose | $780.00 | $812.00 |
| Trulicity | Dulaglutide | 1.5 mg/dose | $860.00 | $892.00 |
| Ozempic | Semaglutide | 1 mg/dose | $920.00 | $968.00 |
| Mounjaro | Tirzepatide | 5 mg/dose | $1020.00 | $1069.00 |
FAQ
What is the cheapest medication for Diabetes?
Generic Insulin Glargine-yfgn (Semglee) averages $0.00 cash. Cost Plus and Costco usually have the lowest verified prices.
Can I fill Diabetes medications without insurance?
Yes. Every drug on this page can be filled cash-pay at any US pharmacy. Generic versions are usually under $15/month at Cost Plus, Costco, or with a GoodRx coupon.
Are generic Diabetes drugs as good as brand?
Yes — the FDA requires generics to contain the same active ingredient at the same strength as the brand and to be therapeutically equivalent.