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Blood Pressure

Zestril

Lisinopril · 20 mg · tablet · qty 30

Also available in: 2.5mg · 5mg · 10mg · 20mg · 40mg

ACE inhibitor for hypertension.

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Common uses & information

Zestril is a brand of Lisinopril, a blood pressure medication supplied as tablet in a 20 mg strength. It is commonly used for aCE inhibitor for hypertension.

An FDA-approved generic (Lisinopril) is available and typically costs less than the brand — compare both cash prices in the table above before you fill.

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Price summary

FormClassBrand avgGeneric avgSavings
tablet 20 mgRx$78.00 — generic is cheaper, see recommendation$3.80Generic recommended95%

Clinical information

Typical dosing

Dose depends on indication — do not use one number for all patients: • Hypertension: typical starting dose 10 mg once daily; usual maintenance 20–40 mg once daily. • Heart failure: start LOW — 2.5–5 mg once daily — then titrate upward as tolerated (target doses used in clinical trials were 20–40 mg/day). Starting HF patients at 10 mg risks symptomatic low blood pressure. • Post-heart-attack: started at low dose (2.5–5 mg) within 24 hours as tolerated, per prescriber.

Side effects

Common: dry cough, dizziness, headache. Serious (rare): swelling of face/lips/throat (angioedema), high potassium, kidney problems, symptomatic hypotension (especially after the first dose in heart-failure or volume-depleted patients).

Interactions to know

Avoid potassium supplements and salt substitutes containing potassium unless your doctor says otherwise. NSAIDs can reduce its effect and worsen kidney function.

Pregnancy & breastfeeding

Do not use during pregnancy — can cause fetal harm, especially in the 2nd/3rd trimester.

Clinical content reviewed by the BetterBuyRx clinical team, on 2026-07-07. Read the full wiki entry and sources →

Manufacturer & patient assistance programs

For patient assistance, check NeedyMeds and RxAssist.

Other brands of Lisinopril

Same active ingredient, different brand. Compare prices.

FAQ

Is generic Lisinopril the same as Zestril?

Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.

How much can I save by choosing the generic?

On average $74.20 per fill (95% off the brand price). Savings vary by pharmacy — see live prices above.

Do I need insurance to get this price?

No. The prices shown on BetterBuyRx are cash prices. Often these beat insurance copays for generics.

How often is this price updated?

At minimum every 72 hours. Many sources refresh every few hours.

Related medications

Compare Zestril with other options and see the generic price.

Information for general comparison only. Not medical advice. Confirm with your pharmacist.