Lisinopril
Sold as Prinivil, Zestril
Lisinopril is an ACE inhibitor used to treat high blood pressure and heart failure, and to improve survival after a heart attack.
As of August 2026, Lisinopril (20 mg) cash prices on BetterBuyRx start at $3.50 across 10 verified sources (lowest at Blink Health). The free BetterBuyRx discount card recently showed $7.04 in the 303xx ZIP area (checked Aug 22, 2026); card prices vary by ZIP, so enter yours on the drug page for local pharmacy prices. Prices change; confirm at the counter.
What it treats
High blood pressure (hypertension), heart failure (HF), and improving survival after a heart attack (acute myocardial infarction).
Typical dosing
Dose depends on indication, do not use one number for all patients: • Hypertension: typical starting dose 10 mg once daily; usual maintenance 20-40 mg once daily. • Heart failure: start LOW, 2.5-5 mg once daily, then titrate upward as tolerated (target doses used in clinical trials were 20-40 mg/day). Starting HF patients at 10 mg risks symptomatic low blood pressure. • Post-heart-attack: started at low dose (2.5-5 mg) within 24 hours as tolerated, per prescriber.
Side effects
Common: dry cough, dizziness, headache. Serious (rare): swelling of face/lips/throat (angioedema), high potassium, kidney problems, symptomatic hypotension (especially after the first dose in heart-failure or volume-depleted patients).
Interactions to know
Avoid potassium supplements and salt substitutes containing potassium unless your doctor says otherwise. NSAIDs can reduce its effect and worsen kidney function.
Pregnancy & breastfeeding
Do not use during pregnancy, can cause fetal harm, especially in the 2nd/3rd trimester.
Live price snapshot
| Source | Type | Cash price |
|---|---|---|
| Blink Health | pharmacy | $3.50 |
| H-E-B Pharmacy | program | $4.00 |
| Costco Pharmacy | pharmacy | $4.00 |
| Amazon Pharmacy RxPass | program | $5.00 |
| Mark Cuban Cost Plus | pharmacy | $5.55 |
| Honeybee Health | pharmacy | $6.60 |
Save with the free BetterBuyRx card
The BetterBuyRx discount card is free, no signup, no insurance needed. It recently showed $7.04 for Lisinopril at a partner-network pharmacy in the 303xx ZIP area, card prices vary by ZIP, so enter yours on the drug page for local pharmacy prices. Show the card at the pharmacy counter; it can't be combined with insurance.
Frequently asked questions
- How much does Lisinopril cost without insurance?
- As of the latest check, the lowest verified cash price we've found for Lisinopril is $3.50 at Blink Health, across 10 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.
- Is there a generic for Lisinopril?
- Yes. Lisinopril is the generic; it is also sold under brand names such as Prinivil, Zestril. The generic is typically far cheaper than brand and is what our verified cash prices reflect.
- Can I use the free BetterBuyRx discount card for Lisinopril?
- Yes. The free BetterBuyRx discount card recently showed $7.04 for this medication at a partner-network pharmacy in the 303xx ZIP area (checked Aug 22, 2026). Card prices vary by ZIP, enter yours on the drug page to see local pharmacy prices. Show the card (BIN, PCN, Group, and Member ID where required) at the counter; it can't be combined with insurance.
- Why does the price of Lisinopril vary so much between pharmacies?
- U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the ACE inhibitor class). That's why comparing verified prices before you fill can save money.
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Clinical content reviewed by the BetterBuyRx clinical team, on 2026-07-07.
Educational only. Not medical advice. Always confirm with your prescriber or pharmacist.