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Mental Health

Zoloft

Sertraline · 50 mg · tablet · qty 30

Also available in: 25mg · 50mg · 100mg

Depression, anxiety, OCD, PTSD.

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Common uses & information

Zoloft is a brand of Sertraline, a mental health medication supplied as tablet in a 50 mg strength. It is commonly used for depression, anxiety, OCD, PTSD.

An FDA-approved generic (Sertraline) is available and typically costs less than the brand — compare both cash prices in the table above before you fill.

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Price summary

FormClassBrand avgGeneric avgSavings
tablet 50 mgRx$178.00 — generic is cheaper, see recommendation$5.20Generic recommended97%

Clinical information

Typical dosing

Typical adult starting dose: 50 mg once daily; range 50–200 mg/day.

Side effects

Common: nausea, diarrhea, insomnia, sexual side effects, sweating. Serious (rare): serotonin syndrome, abnormal bleeding, activation of mania in bipolar disorder.

Interactions to know

⚠️ MAOI washout: Do NOT use sertraline within 14 days of stopping an MAOI (e.g. phenelzine, tranylcypromine, selegiline, linezolid, IV methylene blue) — and do not start an MAOI within 14 days of stopping sertraline. Combining them can cause serotonin syndrome, which can be fatal. Caution with NSAIDs and blood thinners (bleeding risk), and with other serotonergic drugs (triptans, tramadol, other antidepressants).

Pregnancy & breastfeeding

Discuss with prescriber — risk-benefit decision.

Clinical content reviewed by the BetterBuyRx clinical team, on 2026-07-07. Read the full wiki entry and sources →

Manufacturer & patient assistance programs

For patient assistance, check NeedyMeds and RxAssist.

FAQ

Is generic Sertraline the same as Zoloft?

Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.

How much can I save by choosing the generic?

On average $172.80 per fill (97% off the brand price). Savings vary by pharmacy — see live prices above.

Do I need insurance to get this price?

No. The prices shown on BetterBuyRx are cash prices. Often these beat insurance copays for generics.

How often is this price updated?

At minimum every 72 hours. Many sources refresh every few hours.

Related medications

Compare Zoloft with other options and see the generic price.

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Information for general comparison only. Not medical advice. Confirm with your pharmacist.