Prozac
Generic Fluoxetine · capsule · Rx required · SSRI for depression, OCD.
Fetching live prices…
The lowest verified cash price for Prozac 20 mg is $4.00 at H-E-B Pharmacy, based on 8 verified pharmacy prices checked August 23, 2026.
Local BetterBuy Rx prices near you
Enter your ZIP to check real pharmacy prices in your area with the free BetterBuy Rx discount card. No ZIP? The national price is in the results above.
How much does Prozac cost without insurance?
The lowest verified cash price for Prozac 20 mg is $4.00 at H-E-B Pharmacy, based on 8 verified pharmacy prices checked August 23, 2026. Across 8 verified pharmacy prices, cash costs range from $4.00 to $47.00. These are cash prices, no insurance or signup is required, and for many generics the cash price beats a typical insurance copay. Prices vary by pharmacy, location, quantity, and eligibility; confirm the final price at the counter.
About Prozac
Prozac is a brand of Fluoxetine, a mental health medication supplied as capsule in a 20 mg strength. It is commonly used for sSRI for depression, OCD.
An FDA-approved generic (Fluoxetine) is available and typically costs less than the brand, compare both cash prices in the results above before you fill.
Ways to save on Prozac
Choosing the generic (Fluoxetine) instead of the brand can lower your cost, on average about $143.60 per fill (97% off the brand price) in our catalog, though the exact price varies by pharmacy, location, quantity, and eligibility. Compare the live cash and discount prices above, and ask about a 90-day supply if you take it long-term.
Related savings guides
Clinical information
Typical dosing
Typical adult dose: 20 mg once daily, range 20-80 mg.
Side effects
Insomnia, jitteriness, sexual side effects, GI upset.
Interactions to know
Do not combine with MAOIs. Strong CYP2D6 inhibitor, affects many other meds.
Pregnancy & breastfeeding
Risk-benefit discussion.
Clinical content reviewed by the BetterBuyRx clinical team. Read the full wiki entry and sources →
Frequently asked questions
How much does Prozac cost without insurance?
The lowest verified cash price for Prozac 20 mg is $4.00 at H-E-B Pharmacy, based on 8 verified pharmacy prices checked August 23, 2026. These are cash prices, no insurance or signup needed, and refresh at least every 72 hours.
Is generic Fluoxetine the same as Prozac?
Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.
How much can I save by choosing the generic?
On average $143.60 per fill (97% off the brand price). Savings vary by pharmacy, see live prices above.
Do I need insurance to get this price?
No. The prices shown on BetterBuyRx are cash prices. Often these beat insurance copays for generics.
How often is this price updated?
At minimum every 72 hours. Many sources refresh every few hours.
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Important safety information
Information for general comparison only. Not medical advice. Confirm with your pharmacist.