Depression and Anxiety medication prices (2026)
SSRIs (sertraline, escitalopram, fluoxetine) and SNRIs (duloxetine, venlafaxine) are first-line antidepressants. Most have generic versions under $10/month cash. Brand Lexapro and Cymbalta can be 10× more expensive than their generics.
All Depression & anxiety medications ranked by cash price
| Brand | Generic | Strength | Generic cash | Brand cash |
|---|---|---|---|---|
| Wellbutrin SR | Bupropion | 150 mg | see live | see live |
| Luvox | Fluvoxamine | 100 mg | see live | see live |
| Viibryd | Vilazodone | 40 mg | see live | see live |
| Trintellix | Vortioxetine | 10 mg | see live | see live |
| Geodon | Ziprasidone | 40 mg | see live | see live |
| Invega | Paliperidone | 6 mg | see live | see live |
| Latuda | Lurasidone | 40 mg | see live | see live |
| Clozaril | Clozapine | 100 mg | see live | see live |
| Haldol | Haloperidol | 5 mg | see live | see live |
| Rexulti | Brexpiprazole | 2 mg | see live | see live |
| Vraylar | Cariprazine | 3 mg | see live | see live |
| Anafranil | Clomipramine | 75mg | see live | $2100.74 |
| Caplyta | Lumateperone | 42mg | see live | $1682.95 |
| Cobenfy | Xanomeline/Trospium | 100mg/20mg | see live | $1865.63 |
| Exxua | Gepirone | 36.3mg | see live | see live |
| Fanapt | Iloperidone | 6mg | see live | $2547.45 |
| Fetzima | Levomilnacipran | 40mg | see live | $493.69 |
| Ketamine Oral | Ketamine Oral | standard | see live | see live |
| Ludiomil | Maprotiline | 50mg | see live | see live |
| Marplan | Isocarboxazid | 10mg | see live | $293.36 |
| Moban | Molindone | 25mg | see live | $822.68 |
| Nardil | Phenelzine | 15mg | see live | $146.15 |
| Nuplazid | Pimavanserin | 34mg | see live | $4967.04 |
| Parnate | Tranylcypromine | 10mg | see live | $553.82 |
| Spravato | Esketamine | 56mg | see live | $1515.65 |
| Surmontil | Trimipramine | 50mg | see live | $226.78 |
| Zulresso | Brexanolone | 100mg/20mL | see live | see live |
| Zurzuvae | Zuranolone | 50mg | see live | $8006.55 |
| Desyrel | Trazodone | 50 mg | $4.20 | $78.00 |
| Prozac | Fluoxetine | 20 mg | $4.40 | $148.00 |
| Zoloft | Sertraline | 50 mg | $5.20 | $178.00 |
| Vistaril | Hydroxyzine Pamoate | 25 mg | $5.20 | $62.00 |
| Celexa | Citalopram | 20 mg | $5.80 | $168.00 |
| Remeron | Mirtazapine | 15 mg | $7.20 | $168.00 |
| Lexapro | Escitalopram | 10 mg | $7.40 | $212.00 |
| Xanax | Alprazolam | 0.5 mg | $7.40 | $92.00 |
| Valium | Diazepam | 5 mg | $7.40 | $112.00 |
| Paxil | Paroxetine | 20 mg | $7.80 | $182.00 |
| Ativan | Lorazepam | 1 mg | $8.20 | $98.00 |
| BuSpar | Buspirone | 10 mg | $8.40 | $112.00 |
| Wellbutrin | Bupropion | 150 mg | $8.76 | $2242.66 |
| Lamictal | Lamotrigine | 100 mg | $9.40 | $312.00 |
| Klonopin | Clonazepam | 0.5 mg | $9.80 | $142.00 |
| Lybalvi | Olanzapine/Samidorphan | 10mg/10mg | $11.40 | $1608.70 |
| Cymbalta | Duloxetine | 60 mg | $11.80 | $289.00 |
| Effexor XR | Venlafaxine | 75 mg | $12.20 | $312.00 |
| Seroquel | Quetiapine | 100 mg | $12.40 | $612.00 |
| Risperdal | Risperidone | 2 mg | $12.40 | $612.00 |
| Tofranil | Imipramine | 50mg | $13.82 | $13.82 |
| Abilify | Aripiprazole | 10 mg | $18.00 | $892.00 |
| Wellbutrin XL | Bupropion | 300 mg | $18.40 | $398.00 |
| Zyprexa | Olanzapine | 10 mg | $18.40 | $898.00 |
| Mellaril | Thioridazine | 25mg | $38.68 | $38.68 |
| Trilafon | Perphenazine | 8mg | $43.01 | $49.12 |
| Norpramin | Desipramine | 75mg | $47.02 | $47.02 |
| Adasuve | Loxapine | 25mg | $47.47 | $47.47 |
| Stelazine | Trifluoperazine | 5mg | $50.11 | $50.11 |
| Thorazine | Chlorpromazine | 25mg | $69.30 | $199.36 |
| Prolixin | Fluphenazine | 5mg | $71.14 | $131.99 |
| Navane | Thiothixene | 5mg | $77.28 | $77.28 |
| Orap | Pimozide | 2mg | $88.22 | $88.22 |
| Serzone | Nefazodone | 150mg | $107.90 | $107.90 |
| Vivactil | Protriptyline | 10mg | $162.46 | $162.46 |
| Savella | Milnacipran | 50mg | $477.41 | $477.41 |
| Saphris | Asenapine | 5mg | $683.71 | $1176.61 |
FAQ
What is the cheapest medication for Depression & anxiety?
Generic Bupropion (Wellbutrin SR) averages $0.00 cash. Cost Plus and Costco usually have the lowest verified prices.
Can I fill Depression & anxiety medications without insurance?
Yes. Every drug on this page can be filled cash-pay at any US pharmacy. Generic versions are usually under $15/month at Cost Plus, Costco, or with a GoodRx coupon.
Are generic Depression & anxiety drugs as good as brand?
Yes — the FDA requires generics to contain the same active ingredient at the same strength as the brand and to be therapeutically equivalent.