How much does Zoloft cost without insurance?

Zoloft (Sertraline) 50 mg costs around $5.20 cash for the generic and $178.00 for the brand. Live prices on this page are verified within the last 72 hours.

What pharmacy has the cheapest Zoloft?

Cost Plus Drugs and Costco typically have the lowest cash price for generic Sertraline. CVS and Walgreens are the most expensive. Exact rankings update live above.

Which pharmacy has the cheapest Zoloft in 2026?

Mark Cuban Cost Plus currently has the lowest verified cash price for Zoloft (Sertraline) at $2.86. Cost Plus Drugs and Costco are consistently the cheapest US pharmacies for most generics.

Is CVS or Walgreens cheaper for Zoloft?

Neither — both are typically 30–60% more expensive than Cost Plus or Costco. CVS and Walgreens consistently rank as the most expensive cash-pay pharmacies for Sertraline.

How often do these prices change?

BetterBuyRx refreshes prices at minimum every 72 hours from public retail price feeds. Mail-order partners like Cost Plus and Amazon Pharmacy can change daily.

Mental Health

Zoloft

Name: Zoloft 50 mg (Sertraline)
Brand: Zoloft
SKU: zoloft
Availability: InStock

Sertraline · 50 mg · tablet · qty 30

Also available in: 25mg · 50mg · 100mg

Depression, anxiety, OCD, PTSD.

See live generic prices →🔔 Price alert

Live verified prices

Fetching live quotes…

Common uses & information

Zoloft is a brand of Sertraline, a mental health medication supplied as tablet in a 50 mg strength. It is commonly used for depression, anxiety, OCD, PTSD.

An FDA-approved generic (Sertraline) is available and typically costs less than the brand — compare both cash prices in the table above before you fill.

Got questions?

Chat available now

Want to dig deeper on Zoloft 50 mg?

Ask about generic alternatives, coverage, dosing, or have an agent widen the search to other pharmacies near you.

Price summary

Form	Class	Brand avg	Generic avg	Savings
tablet 50 mg	Rx	$178.00 — generic is cheaper, see recommendation	$5.20Generic recommended	97%

Clinical information

Boxed warning

Increased risk of suicidal thinking and behavior in children, adolescents, and young adults (up to age 24), especially in the first weeks of treatment or after a dose change. Monitor closely for worsening mood or new suicidal thoughts.

Typical dosing

Typical adult starting dose: 50 mg once daily; range 50–200 mg/day.

Side effects

Common: nausea, diarrhea, insomnia, sexual side effects, sweating. Serious (rare): serotonin syndrome, abnormal bleeding, activation of mania in bipolar disorder.

Interactions to know

⚠️ MAOI washout: Do NOT use sertraline within 14 days of stopping an MAOI (e.g. phenelzine, tranylcypromine, selegiline, linezolid, IV methylene blue) — and do not start an MAOI within 14 days of stopping sertraline. Combining them can cause serotonin syndrome, which can be fatal. Caution with NSAIDs and blood thinners (bleeding risk), and with other serotonergic drugs (triptans, tramadol, other antidepressants).

Pregnancy & breastfeeding

Discuss with prescriber — risk-benefit decision.

Clinical content reviewed by the BetterBuyRx clinical team, on 2026-07-07. Read the full wiki entry and sources →

Manufacturer & patient assistance programs

For patient assistance, check NeedyMeds and RxAssist.

FAQ

Is generic Sertraline the same as Zoloft?

Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.

How much can I save by choosing the generic?

On average $172.80 per fill (97% off the brand price). Savings vary by pharmacy — see live prices above.

Do I need insurance to get this price?

No. The prices shown on BetterBuyRx are cash prices. Often these beat insurance copays for generics.

How often is this price updated?

At minimum every 72 hours. Many sources refresh every few hours.

Related medications

Compare Zoloft with other options and see the generic price.

See generic Sertraline prices →

Depression & anxiety medications →

Other drugs for Depression & anxiety

Cheapest Zoloft alternatives

Compare Zoloft with…

Save more on Zoloft

Information for general comparison only. Not medical advice. Confirm with your pharmacist.