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How much does Prednisone 5 mg cost without insurance?

As of September 2026, the lowest verified cash price for Prednisone 5 mg (Prednisone) is $4.00 at H-E-B Pharmacy, based on 5 verified US pharmacy quotes. You don't need insurance to fill it, every price below is a real quote we verified, not an estimate or an insurance copay.

BetterBuyRx card price in the 601xx ZIP area: $6.20 (checked Sep 3, 2026). Card prices vary by ZIP, enter yours on the drug page for local pharmacy prices. We show home delivery too and always surface it first when it is cheaper.

Pharmacy / sourceTypeVerified cash price
H-E-B Pharmacyprogram$4.00
Costco Pharmacypharmacy$4.00
Mark Cuban Cost Pluspharmacy$5.69
BetterBuy Rxcoupon$7.19
Honeybee Healthpharmacy$16.00

Last verified Sep 4, 2026. Cash prices only, from verified public retail and mail-order sources, no insurance copays, no estimates, no extrapolation across strengths or quantities. Prices change; confirm at the pharmacy counter. See our methodology.

Common questions

What is the cheapest way to buy Prednisone 5 mg without insurance?
The lowest verified cash price we currently have for Prednisone 5 mg (Prednisone) is $4.00 at H-E-B Pharmacy, from 5 verified pharmacy quotes. Prices change; confirm at the pharmacy before you buy.
Is the BetterBuyRx card or home delivery cheaper for Prednisone?
Home delivery/retail is cheaper here: the lowest verified quote is $4.00 versus $6.20 on the BetterBuyRx card in the 601xx ZIP area for Prednisone 5 mg. Card prices vary by ZIP, enter yours on the drug page for local pharmacy prices. We show the delivery option first because it is the lower price.
Is a generic version of Prednisone available?
Prednisone is dispensed as Prednisone. Cash prices above reflect what US pharmacies verified most recently.

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