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How much does Prilosec 20 mg cost without insurance?

As of July 2026, the lowest verified cash price for Prilosec 20 mg (Omeprazole) is $4.50 at Costco Pharmacy, based on 46 verified US pharmacy quotes. You don't need insurance to fill it — every price below is a real quote we verified, not an estimate or an insurance copay.

Pharmacy / sourceTypeVerified cash price
Costco Pharmacypharmacy$4.50
Costco Pharmacypharmacy$4.50
Blink Healthpharmacy$5.00
Amazon Pharmacy RxPassprogram$5.00
Amazon Pharmacy RxPassprogram$5.00
Amazon Pharmacy RxPassprogram$5.00

Last verified Jul 21, 2026. Cash prices only, from verified public retail and mail-order sources — no insurance copays, no estimates, no extrapolation across strengths or quantities. Prices change; confirm at the pharmacy counter. See our methodology.

Common questions

What is the cheapest way to buy Prilosec 20 mg without insurance?
The lowest verified cash price we currently have for Prilosec 20 mg (Omeprazole) is $4.50 at Costco Pharmacy, from 46 verified pharmacy quotes. Prices change; confirm at the pharmacy before you buy.
Is a generic version of Prilosec available?
Yes — Omeprazole is the generic of Prilosec and is what drives the low cash prices above.

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