What is the generic of Prilosec?
The generic of Prilosec is Omeprazole. As of July 2026, the lowest verified cash price for Omeprazole 20 mg is $4.50 at Costco Pharmacy, based on 46 verified US pharmacy quotes — every price below is a real quote we verified, not an estimate.
| Pharmacy / source | Type | Verified cash price |
|---|---|---|
| Costco Pharmacy | pharmacy | $4.50 |
| Costco Pharmacy | pharmacy | $4.50 |
| Blink Health | pharmacy | $5.00 |
| Amazon Pharmacy RxPass | program | $5.00 |
| Amazon Pharmacy RxPass | program | $5.00 |
| Amazon Pharmacy RxPass | program | $5.00 |
Last verified Jul 21, 2026. Cash prices only, from verified public retail and mail-order sources — no insurance copays, no estimates, no extrapolation across strengths or quantities. Prices change; confirm at the pharmacy counter. See our methodology.
Common questions
- What is the generic of Prilosec?
- The generic of Prilosec is Omeprazole. It contains the same active ingredient and is the version that drives the low cash prices below.
- How much does generic Prilosec (Omeprazole) cost without insurance?
- The lowest verified cash price we currently have for Omeprazole 20 mg is $4.50 at Costco Pharmacy, from 46 verified US pharmacy quotes. Prices change; confirm at the pharmacy before you buy.
- Is generic Omeprazole as effective as Prilosec?
- Generic Omeprazole must meet the same FDA standards for active ingredient, strength, and quality as Prilosec. Ask your pharmacist if you have questions about switching.