Prilosec
Generic Omeprazole · tablet · Rx required · See prescribing information.
Fetching live prices…
The lowest verified cash price for Prilosec 20 mg is $4.50 at Costco Pharmacy, based on 20 verified pharmacy prices checked August 27, 2026.
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How much does Prilosec cost without insurance?
The lowest verified cash price for Prilosec 20 mg is $4.50 at Costco Pharmacy, based on 20 verified pharmacy prices checked August 27, 2026. Across 20 verified pharmacy prices, cash costs range from $4.50 to $78.00. These are cash prices, no insurance or signup is required, and for many generics the cash price beats a typical insurance copay. Prices vary by pharmacy, location, quantity, and eligibility; confirm the final price at the counter.
Prilosec is commonly dispensed as tablet in 10mg, 20mg, 40mg strengths. Price varies by strength, quantity, and pharmacy, set your strength and quantity above to see the cash price for your exact fill.
About Prilosec
Prilosec is a brand of Omeprazole, a other medication supplied as tablet in a 20 mg strength. It is commonly used for see prescribing information.
An FDA-approved generic (Omeprazole) is available and typically costs less than the brand, compare both cash prices in the results above before you fill.
Ways to save on Prilosec
Choosing the generic (Omeprazole) instead of the brand can lower your cost, on average about $413.90 per fill (90% off the brand price) in our catalog, though the exact price varies by pharmacy, location, quantity, and eligibility. Compare the live cash and discount prices above, and ask about a 90-day supply if you take it long-term.
Don't pay for the Prilosec OTC label
Active ingredient: Omeprazole 20mg delayed release
- ✓CVS Health Omeprazole 20mg
- ✓Walgreens Wal-Zole
- ✓Equate Omeprazole
- ✓Up&Up Omeprazole
- ✓Amazon Basic Care Omeprazole
Active ingredients are taken from the FDA Drug Facts panel (DailyMed). Store-brand prices are typical US shelf estimates and vary by location. Ask the pharmacist if you can't spot the store-brand version.
Clinical information
Typical dosing
OTC: 20 mg once daily for up to 14 days. Rx doses vary by indication, typically 20-40 mg/day.
Side effects
Common: headache, stomach pain, gas, diarrhea. Long-term use: low magnesium, B12 deficiency, slightly increased fracture risk.
Interactions to know
Reduces effectiveness of clopidogrel (Plavix). Affects absorption of certain HIV and antifungal meds.
Pregnancy & breastfeeding
Generally considered low-risk in pregnancy.
Clinical content reviewed by the BetterBuyRx clinical team. Read the full wiki entry and sources →
Other brands of Omeprazole
Same active ingredient, different brand. Compare prices.
Frequently asked questions
How much does Prilosec cost without insurance?
The lowest verified cash price for Prilosec 20 mg is $4.50 at Costco Pharmacy, based on 20 verified pharmacy prices checked August 27, 2026. These are cash prices, no insurance or signup needed, and refresh at least every 72 hours.
Is generic Omeprazole the same as Prilosec?
Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.
How much can I save by choosing the generic?
On average $413.90 per fill (90% off the brand price). Savings vary by pharmacy, see live prices above.
Do I need insurance to get this price?
No. The prices shown on BetterBuyRx are cash prices. Often these beat insurance copays for generics.
How often is this price updated?
At minimum every 72 hours. Many sources refresh every few hours.
Related medications
Compare Prilosec with other options and see the generic price.
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Important safety information
Information for general comparison only. Not medical advice. Confirm with your pharmacist.