Azithromycin
Sold as Zithromax, Z-Pak
Azithromycin is a macrolide antibiotic, often dispensed as a 5-day Z-Pak for respiratory and skin infections.
As of August 2026, Azithromycin (250 mg) cash prices on BetterBuyRx start at $5.40 across 6 verified sources (lowest at Mark Cuban Cost Plus). The free BetterBuyRx discount card is compared live on the drug page when a partner network prices this combo. Prices change; confirm at the counter.
What it treats
Bronchitis, pneumonia, sinusitis, strep throat, some STIs.
Typical dosing
Z-Pak: 500 mg day 1, then 250 mg days 2-5.
Side effects
Diarrhea, nausea, abdominal pain. Rare: QT prolongation.
Interactions to know
Caution with other QT-prolonging drugs and certain anticoagulants.
Pregnancy & breastfeeding
Generally considered low-risk.
Live price snapshot
| Source | Type | Cash price |
|---|---|---|
| Mark Cuban Cost Plus | pharmacy | $5.40 |
| Mark Cuban Cost Plus | pharmacy | $5.88 |
| Costco Pharmacy | pharmacy | $6.49 |
| BetterBuy Rx | coupon | $9.07 |
| Honeybee Health | pharmacy | $29.00 |
| PlanetDrugsDirect | pharmacy | $35.99 |
Save with the free BetterBuyRx card
The BetterBuyRx discount card is free, no signup, no insurance needed. When a partner network prices Azithromycin, the card price appears live on the drug page with its BIN, PCN, Group, and Member ID. Show the card at the pharmacy counter; it can't be combined with insurance.
Frequently asked questions
- How much does Azithromycin cost without insurance?
- As of the latest check, the lowest verified cash price we've found for Azithromycin is $5.40 at Mark Cuban Cost Plus, across 6 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.
- Is there a generic for Azithromycin?
- Yes. Azithromycin is the generic; it is also sold under brand names such as Zithromax, Z-Pak. The generic is typically far cheaper than brand and is what our verified cash prices reflect.
- Can I use the free BetterBuyRx discount card for Azithromycin?
- Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Azithromycin, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.
- Why does the price of Azithromycin vary so much between pharmacies?
- U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the Macrolide antibiotic class). That's why comparing verified prices before you fill can save money.
Clinical content reviewed by the BetterBuyRx clinical team.
Educational only. Not medical advice. Always confirm with your prescriber or pharmacist.