How much does Bupropion cost without insurance?

As of the latest check, the lowest verified cash price we've found for Bupropion is $9.65 at BetterBuy Rx, across 1 verified source. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.

Is there a generic for Bupropion?

Yes. Bupropion is the generic; it is also sold under brand names such as Wellbutrin, Wellbutrin XL, Zyban. The generic is typically far cheaper than brand and is what our verified cash prices reflect.

Can I use the free BetterBuyRx discount card for Bupropion?

Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Bupropion, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.

Why does the price of Bupropion vary so much between pharmacies?

U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the NDRI antidepressant class). That's why comparing verified prices before you fill can save money.

NDRI antidepressantGeneric available

Bupropion

Sold as Wellbutrin, Wellbutrin XL, Zyban

Bupropion is a norepinephrine-dopamine reuptake inhibitor used for depression, seasonal affective disorder, and smoking cessation. Generally weight-neutral and without sexual side effects.

Compare prices →~$18.00 / mo (generic, NADAC)

As of August 2026, Bupropion (150 mg) cash prices on BetterBuyRx start at $9.65 across 1 verified source (lowest at BetterBuy Rx). The free BetterBuyRx discount card is compared live on the drug page when a partner network prices this combo. Prices change; confirm at the counter.

What it treats

Depression, seasonal affective disorder, smoking cessation.

Typical dosing

Wellbutrin XL: 150-300 mg once daily in the morning.

Side effects

Insomnia, dry mouth, headache, decreased appetite. Lowers seizure threshold.

Interactions to know

Avoid in patients with seizure disorders, eating disorders, or abrupt alcohol/benzo withdrawal.

Pregnancy & breastfeeding

Risk-benefit discussion.

Live price snapshot

Source	Type	Cash price
BetterBuy Rx	coupon	$9.65

See all prices for Bupropion →Prices checked Aug 27, 2026

Save with the free BetterBuyRx card

The BetterBuyRx discount card is free, no signup, no insurance needed. When a partner network prices Bupropion, the card price appears live on the drug page with its BIN, PCN, Group, and Member ID. Show the card at the pharmacy counter; it can't be combined with insurance.

Get the free card →Bupropion coupon & card price →

Frequently asked questions

How much does Bupropion cost without insurance?: As of the latest check, the lowest verified cash price we've found for Bupropion is $9.65 at BetterBuy Rx, across 1 verified source. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.
Is there a generic for Bupropion?: Yes. Bupropion is the generic; it is also sold under brand names such as Wellbutrin, Wellbutrin XL, Zyban. The generic is typically far cheaper than brand and is what our verified cash prices reflect.
Can I use the free BetterBuyRx discount card for Bupropion?: Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Bupropion, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.
Why does the price of Bupropion vary so much between pharmacies?: U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the NDRI antidepressant class). That's why comparing verified prices before you fill can save money.

Clinical content reviewed by the BetterBuyRx clinical team.

Educational only. Not medical advice. Always confirm with your prescriber or pharmacist.