How much does Bupropion cost without insurance?

As of the latest check, the lowest verified cash price we've found for Bupropion is $6.86 at Mark Cuban Cost Plus, across 3 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.

Can I use the free BetterBuyRx discount card for Bupropion?

Yes. The free BetterBuyRx discount card recently showed $12.39 for this medication at a partner-network pharmacy in the 750xx ZIP area (checked Aug 23, 2026). Card prices vary by ZIP, enter yours on the drug page to see local pharmacy prices. Show the card (BIN, PCN, Group, and Member ID where required) at the counter; it can't be combined with insurance.

Why does the price of Bupropion vary so much between pharmacies?

U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the Mental Health class). That's why comparing verified prices before you fill can save money.

Mental Health

Bupropion

Sold as Wellbutrin SR

Bupropion (sold as Wellbutrin SR) is used for: NDRI, sustained-release (twice daily); depression, smoking cessation. Distinct from Wellbutrin XL (once-daily) and immediate-release bupropion.

Compare prices →~$0.00 / mo (generic, NADAC)

As of August 2026, Bupropion (150 mg) cash prices on BetterBuyRx start at $6.86 across 3 verified sources (lowest at Mark Cuban Cost Plus). The free BetterBuyRx discount card recently showed $12.39 in the 750xx ZIP area (checked Aug 23, 2026); card prices vary by ZIP, so enter yours on the drug page for local pharmacy prices. Prices change; confirm at the counter.

Live price snapshot

Source	Type	Cash price
Mark Cuban Cost Plus	pharmacy	$6.86
PlanetDrugsDirect	pharmacy	$68.99
RxConnected.com	pharmacy	$100.00

See all prices for Bupropion →Prices checked Aug 21, 2026

Save with the free BetterBuyRx card

The BetterBuyRx discount card is free, no signup, no insurance needed. It recently showed $12.39 for Bupropion at a partner-network pharmacy in the 750xx ZIP area, card prices vary by ZIP, so enter yours on the drug page for local pharmacy prices. Show the card at the pharmacy counter; it can't be combined with insurance.

Get the free card →Bupropion coupon & card price →

Frequently asked questions

How much does Bupropion cost without insurance?: As of the latest check, the lowest verified cash price we've found for Bupropion is $6.86 at Mark Cuban Cost Plus, across 3 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.
Can I use the free BetterBuyRx discount card for Bupropion?: Yes. The free BetterBuyRx discount card recently showed $12.39 for this medication at a partner-network pharmacy in the 750xx ZIP area (checked Aug 23, 2026). Card prices vary by ZIP, enter yours on the drug page to see local pharmacy prices. Show the card (BIN, PCN, Group, and Member ID where required) at the counter; it can't be combined with insurance.
Why does the price of Bupropion vary so much between pharmacies?: U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the Mental Health class). That's why comparing verified prices before you fill can save money.

We're still expanding this entry. For full prescribing information, see the FDA label below.

Clinical content reviewed by the BetterBuyRx clinical team.

Educational only. Not medical advice. Always confirm with your prescriber or pharmacist.