Hydrochlorothiazide
Sold as Microzide
A thiazide diuretic ('water pill') for high blood pressure and fluid retention.
As of August 2026, Hydrochlorothiazide (25 mg) cash prices on BetterBuyRx start at $4.00 across 6 verified sources (lowest at Walmart $4/$10 generic list). The free BetterBuyRx discount card is compared live on the drug page when a partner network prices this combo. Prices change; confirm at the counter.
What it treats
Hypertension, edema from heart failure, kidney or liver disease.
Typical dosing
Typical adult dose: 12.5-25 mg once daily.
Side effects
Increased urination, low potassium, low sodium, increased uric acid (gout flares), photosensitivity.
Interactions to know
Lithium toxicity risk. NSAIDs reduce effect.
Pregnancy & breastfeeding
Generally avoided unless needed.
Live price snapshot
| Source | Type | Cash price |
|---|---|---|
| Walmart $4/$10 generic list | program | $4.00 |
| Costco Pharmacy | pharmacy | $4.00 |
| H-E-B Pharmacy | program | $4.00 |
| Mark Cuban Cost Plus | pharmacy | $5.24 |
| Honeybee Health | pharmacy | $5.60 |
| HealthWarehouse | pharmacy | $9.30 |
Save with the free BetterBuyRx card
The BetterBuyRx discount card is free, no signup, no insurance needed. When a partner network prices Hydrochlorothiazide, the card price appears live on the drug page with its BIN, PCN, Group, and Member ID. Show the card at the pharmacy counter; it can't be combined with insurance.
Frequently asked questions
- How much does Hydrochlorothiazide cost without insurance?
- As of the latest check, the lowest verified cash price we've found for Hydrochlorothiazide is $4.00 at Walmart $4/$10 generic list, across 6 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.
- Is there a generic for Hydrochlorothiazide?
- Yes. Hydrochlorothiazide is the generic; it is also sold under brand names such as Microzide. The generic is typically far cheaper than brand and is what our verified cash prices reflect.
- Can I use the free BetterBuyRx discount card for Hydrochlorothiazide?
- Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Hydrochlorothiazide, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.
- Why does the price of Hydrochlorothiazide vary so much between pharmacies?
- U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the Thiazide diuretic class). That's why comparing verified prices before you fill can save money.
Clinical content reviewed by the BetterBuyRx clinical team.
Educational only. Not medical advice. Always confirm with your prescriber or pharmacist.