How much does Letrozole cost without insurance?

As of the latest check, the lowest verified cash price we've found for Letrozole is $7.48 at Mark Cuban Cost Plus, across 5 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.

Can I use the free BetterBuyRx discount card for Letrozole?

Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Letrozole, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.

Why does the price of Letrozole vary so much between pharmacies?

U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the Fertility & hormonal oncology agents class). That's why comparing verified prices before you fill can save money.

Fertility & hormonal oncology agents

Letrozole

Sold as Femara

Letrozole (sold as Femara) is used for: Aromatase inhibitor for breast cancer/fertility.

Compare prices →~$0.00 / mo (generic, NADAC)

As of August 2026, Letrozole (2.5 mg) cash prices on BetterBuyRx start at $7.48 across 5 verified sources (lowest at Mark Cuban Cost Plus). The free BetterBuyRx discount card is compared live on the drug page when a partner network prices this combo. Prices change; confirm at the counter.

Live price snapshot

Source	Type	Cash price
Mark Cuban Cost Plus	pharmacy	$7.48
Blink Health	pharmacy	$9.60
Honeybee Health	pharmacy	$10.00
BetterBuy Rx	coupon	$10.62
PlanetDrugsDirect	pharmacy	$48.99

See all prices for Letrozole →Prices checked Aug 24, 2026

Save with the free BetterBuyRx card

The BetterBuyRx discount card is free, no signup, no insurance needed. When a partner network prices Letrozole, the card price appears live on the drug page with its BIN, PCN, Group, and Member ID. Show the card at the pharmacy counter; it can't be combined with insurance.

Get the free card →Letrozole coupon & card price →

Frequently asked questions

How much does Letrozole cost without insurance?: As of the latest check, the lowest verified cash price we've found for Letrozole is $7.48 at Mark Cuban Cost Plus, across 5 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.
Can I use the free BetterBuyRx discount card for Letrozole?: Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Letrozole, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.
Why does the price of Letrozole vary so much between pharmacies?: U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the Fertility & hormonal oncology agents class). That's why comparing verified prices before you fill can save money.

Related drugs in this class

We're still expanding this entry. For full prescribing information, see the FDA label below.

Clinical content reviewed by the BetterBuyRx clinical team.

Educational only. Not medical advice. Always confirm with your prescriber or pharmacist.