Levothyroxine
Sold as Synthroid, Levoxyl, Unithroid
Levothyroxine replaces or supplements thyroid hormone for people with an underactive thyroid (hypothyroidism). It is one of the most-prescribed medications in the US.
As of August 2026, Levothyroxine (100 mcg) cash prices on BetterBuyRx start at $4.50 across 9 verified sources (lowest at Costco Pharmacy). The free BetterBuyRx discount card recently showed $4.00 in the 750xx ZIP area (checked Aug 21, 2026); card prices vary by ZIP, so enter yours on the drug page for local pharmacy prices. Prices change; confirm at the counter.
What it treats
Hypothyroidism, thyroid hormone replacement, and management of certain thyroid cancers.
Typical dosing
Take 30-60 minutes before breakfast on an empty stomach with a full glass of water. Dose is individualized by weight and lab tests.
Side effects
Most side effects mean too much hormone: rapid heartbeat, anxiety, weight loss, tremor.
Interactions to know
Calcium, iron, antacids, and some cholesterol meds reduce absorption, separate by 4 hours.
Pregnancy & breastfeeding
Safe in pregnancy; dose often needs to increase.
Live price snapshot
| Source | Type | Cash price |
|---|---|---|
| Costco Pharmacy | pharmacy | $4.50 |
| Mark Cuban Cost Plus | pharmacy | $6.10 |
| Honeybee Health | pharmacy | $7.00 |
| Mark Cuban Cost Plus | pharmacy | $8.31 |
| Costco Pharmacy | pharmacy | $10.50 |
| Honeybee Health | pharmacy | $18.00 |
Save with the free BetterBuyRx card
The BetterBuyRx discount card is free, no signup, no insurance needed. It recently showed $4.00 for Levothyroxine at a partner-network pharmacy in the 750xx ZIP area, card prices vary by ZIP, so enter yours on the drug page for local pharmacy prices. Show the card at the pharmacy counter; it can't be combined with insurance.
Frequently asked questions
- How much does Levothyroxine cost without insurance?
- As of the latest check, the lowest verified cash price we've found for Levothyroxine is $4.50 at Costco Pharmacy, across 9 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.
- Is there a generic for Levothyroxine?
- Yes. Levothyroxine is the generic; it is also sold under brand names such as Synthroid, Levoxyl, Unithroid. The generic is typically far cheaper than brand and is what our verified cash prices reflect.
- Can I use the free BetterBuyRx discount card for Levothyroxine?
- Yes. The free BetterBuyRx discount card recently showed $4.00 for this medication at a partner-network pharmacy in the 750xx ZIP area (checked Aug 21, 2026). Card prices vary by ZIP, enter yours on the drug page to see local pharmacy prices. Show the card (BIN, PCN, Group, and Member ID where required) at the counter; it can't be combined with insurance.
- Why does the price of Levothyroxine vary so much between pharmacies?
- U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the Thyroid hormone class). That's why comparing verified prices before you fill can save money.
Related drugs in this class
Important safety information
Narrow-therapeutic-index medication
This is a narrow-therapeutic-index medication. Do not switch between brand and generic manufacturers without close monitoring by your prescriber. Small differences in absorption can cause treatment failure or toxicity.
Clinical content reviewed by the BetterBuyRx clinical team.
Educational only. Not medical advice. Always confirm with your prescriber or pharmacist.