How much does Lubiprostone 24 cost without insurance?

As of the latest check, the lowest verified cash price we've found for Lubiprostone 24 is $16.73 at Mark Cuban Cost Plus, across 1 verified source. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.

Is there a generic for Lubiprostone 24?

Yes. Lubiprostone 24 is the generic; it is also sold under brand names such as Amitiza 24. The generic is typically far cheaper than brand and is what our verified cash prices reflect.

Can I use the free BetterBuyRx discount card for Lubiprostone 24?

Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Lubiprostone 24, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.

Why does the price of Lubiprostone 24 vary so much between pharmacies?

U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the GI class). That's why comparing verified prices before you fill can save money.

GIGeneric available

Lubiprostone 24

Sold as Amitiza 24

Lubiprostone 24 (sold as Amitiza 24) is used for: Digestive tract condition.

Compare prices →~$0.00 / mo (generic, NADAC)

As of August 2026, Lubiprostone 24 (24mcg) cash prices on BetterBuyRx start at $16.73 across 1 verified source (lowest at Mark Cuban Cost Plus). The free BetterBuyRx discount card is compared live on the drug page when a partner network prices this combo. Prices change; confirm at the counter.

Live price snapshot

Source	Type	Cash price
Mark Cuban Cost Plus	pharmacy	$16.73

See all prices for Lubiprostone 24 →Prices checked Aug 22, 2026

Save with the free BetterBuyRx card

The BetterBuyRx discount card is free, no signup, no insurance needed. When a partner network prices Lubiprostone 24, the card price appears live on the drug page with its BIN, PCN, Group, and Member ID. Show the card at the pharmacy counter; it can't be combined with insurance.

Get the free card →Lubiprostone 24 coupon & card price →

Frequently asked questions

How much does Lubiprostone 24 cost without insurance?: As of the latest check, the lowest verified cash price we've found for Lubiprostone 24 is $16.73 at Mark Cuban Cost Plus, across 1 verified source. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.
Is there a generic for Lubiprostone 24?: Yes. Lubiprostone 24 is the generic; it is also sold under brand names such as Amitiza 24. The generic is typically far cheaper than brand and is what our verified cash prices reflect.
Can I use the free BetterBuyRx discount card for Lubiprostone 24?: Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Lubiprostone 24, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.
Why does the price of Lubiprostone 24 vary so much between pharmacies?: U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the GI class). That's why comparing verified prices before you fill can save money.

We're still expanding this entry. For full prescribing information, see the FDA label below.

Clinical content reviewed by the BetterBuyRx clinical team.

Educational only. Not medical advice. Always confirm with your prescriber or pharmacist.