How much does Methotrexate cost without insurance?

As of the latest check, the lowest verified cash price we've found for Methotrexate is $7.69 at Mark Cuban Cost Plus, across 4 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.

Is there a generic for Methotrexate?

Yes. Methotrexate is the generic; it is also sold under brand names such as Rheumatrex. The generic is typically far cheaper than brand and is what our verified cash prices reflect.

Can I use the free BetterBuyRx discount card for Methotrexate?

Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Methotrexate, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.

Why does the price of Methotrexate vary so much between pharmacies?

U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the Rheumatology class). That's why comparing verified prices before you fill can save money.

RheumatologyGeneric available

Methotrexate

Sold as Rheumatrex

Methotrexate (sold as Rheumatrex) is used for: Rheumatoid arthritis, psoriasis.

Compare prices →~$18.40 / mo (generic, NADAC)

As of August 2026, Methotrexate (2.5 mg) cash prices on BetterBuyRx start at $7.69 across 4 verified sources (lowest at Mark Cuban Cost Plus). The free BetterBuyRx discount card is compared live on the drug page when a partner network prices this combo. Prices change; confirm at the counter.

Live price snapshot

Source	Type	Cash price
Mark Cuban Cost Plus	pharmacy	$7.69
Mark Cuban Cost Plus	pharmacy	$7.70
Honeybee Health	pharmacy	$11.00
PlanetDrugsDirect	pharmacy	$50.99

See all prices for Methotrexate →Prices checked Aug 21, 2026

Save with the free BetterBuyRx card

The BetterBuyRx discount card is free, no signup, no insurance needed. When a partner network prices Methotrexate, the card price appears live on the drug page with its BIN, PCN, Group, and Member ID. Show the card at the pharmacy counter; it can't be combined with insurance.

Get the free card →Methotrexate coupon & card price →

Frequently asked questions

How much does Methotrexate cost without insurance?: As of the latest check, the lowest verified cash price we've found for Methotrexate is $7.69 at Mark Cuban Cost Plus, across 4 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.
Is there a generic for Methotrexate?: Yes. Methotrexate is the generic; it is also sold under brand names such as Rheumatrex. The generic is typically far cheaper than brand and is what our verified cash prices reflect.
Can I use the free BetterBuyRx discount card for Methotrexate?: Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Methotrexate, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.
Why does the price of Methotrexate vary so much between pharmacies?: U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the Rheumatology class). That's why comparing verified prices before you fill can save money.

We're still expanding this entry. For full prescribing information, see the FDA label below.

Clinical content reviewed by the BetterBuyRx clinical team.

Educational only. Not medical advice. Always confirm with your prescriber or pharmacist.