Tacrolimus (extended-release, once-daily)
Sold as Astagraf XL
Tacrolimus (extended-release, once-daily) (sold as Astagraf XL) is used for: Prevents kidney transplant rejection, once-daily extended-release. Different mg dosing than immediate-release Prograf; conversion must be done by a transplant prescriber, never 1:1.
As of August 2026, Tacrolimus (extended-release, once-daily) (0.5 mg) cash prices on BetterBuyRx start at $7.52 across 1 verified source (lowest at Mark Cuban Cost Plus). The free BetterBuyRx discount card is compared live on the drug page when a partner network prices this combo. Prices change; confirm at the counter.
Live price snapshot
| Source | Type | Cash price |
|---|---|---|
| Mark Cuban Cost Plus | pharmacy | $7.52 |
Save with the free BetterBuyRx card
The BetterBuyRx discount card is free, no signup, no insurance needed. When a partner network prices Tacrolimus (extended-release, once-daily), the card price appears live on the drug page with its BIN, PCN, Group, and Member ID. Show the card at the pharmacy counter; it can't be combined with insurance.
Frequently asked questions
- How much does Tacrolimus (extended-release, once-daily) cost without insurance?
- As of the latest check, the lowest verified cash price we've found for Tacrolimus (extended-release, once-daily) is $7.52 at Mark Cuban Cost Plus, across 1 verified source. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.
- Can I use the free BetterBuyRx discount card for Tacrolimus (extended-release, once-daily)?
- Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Tacrolimus (extended-release, once-daily), shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.
- Why does the price of Tacrolimus (extended-release, once-daily) vary so much between pharmacies?
- U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the Transplant class). That's why comparing verified prices before you fill can save money.
Important safety information
Narrow-therapeutic-index medication
This is a narrow-therapeutic-index medication. Do not switch between brand and generic manufacturers without close monitoring by your prescriber. Small differences in absorption can cause treatment failure or toxicity.
We're still expanding this entry. For full prescribing information, see the FDA label below.
Clinical content reviewed by the BetterBuyRx clinical team.
Educational only. Not medical advice. Always confirm with your prescriber or pharmacist.