How much does Advair Diskus cost without insurance?

Advair Diskus (Fluticasone/Salmeterol) 250/50 mcg costs around $178.00 cash for the generic and $412.00 for the brand. Live prices on this page are verified within the last 72 hours.

What pharmacy has the cheapest Advair Diskus?

Cost Plus Drugs and Costco typically have the lowest cash price for generic Fluticasone/Salmeterol. CVS and Walgreens are the most expensive. Exact rankings update live above.

Which pharmacy has the cheapest Advair Diskus in 2026?

Costco Pharmacy currently has the lowest verified cash price for Advair Diskus (Fluticasone/Salmeterol) at $110.36. Cost Plus Drugs and Costco are consistently the cheapest US pharmacies for most generics.

Is CVS or Walgreens cheaper for Advair Diskus?

Neither — both are typically 30–60% more expensive than Cost Plus or Costco. CVS and Walgreens consistently rank as the most expensive cash-pay pharmacies for Fluticasone/Salmeterol.

How often do these prices change?

BetterBuyRx refreshes prices at minimum every 72 hours from public retail price feeds. Mail-order partners like Cost Plus and Amazon Pharmacy can change daily.

Asthma / COPD

Advair Diskus

Name: Advair Diskus 250/50 mcg (Fluticasone/Salmeterol)
Brand: Advair Diskus
SKU: advair
Availability: InStock

Fluticasone/Salmeterol · 250/50 mcg · inhaler · qty 1

Long-term asthma & COPD maintenance.

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Common uses & information

Advair Diskus is a brand of Fluticasone/Salmeterol, a asthma / copd medication supplied as inhaler in a 250/50 mcg strength. It is commonly used for long-term asthma & COPD maintenance.

An FDA-approved generic (Fluticasone/Salmeterol) is available and typically costs less than the brand — compare both cash prices in the table above before you fill.

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Price summary

Form	Class	Brand avg	Generic avg	Savings
inhaler 250/50 mcg	Specialty	$412.00 — generic is cheaper, see recommendation	$178.00Generic recommended	57%

Clinical information

Clinical content reviewed by the BetterBuyRx clinical team. Read the full wiki entry and sources →

Manufacturer & patient assistance programs

For patient assistance, check NeedyMeds and RxAssist.

Other brands of Fluticasone/Salmeterol

Same active ingredient, different brand. Compare prices.

Advair Diskus
250/50 mcg · tablet

FAQ

Is generic Fluticasone/Salmeterol the same as Advair Diskus?

Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.

How much can I save by choosing the generic?

On average $234.00 per fill (57% off the brand price). Savings vary by pharmacy — see live prices above.

Do I need insurance to get this price?

No. The prices shown on BetterBuyRx are cash prices. Often these beat insurance copays for generics.

How often is this price updated?

At minimum every 72 hours. Many sources refresh every few hours.

Related medications

Compare Advair Diskus with other options and see the generic price.

See generic Fluticasone/Salmeterol prices →

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Information for general comparison only. Not medical advice. Confirm with your pharmacist.