Hydrea
Generic Hydroxyurea · capsule · Rx required · Sickle cell disease (reduces painful crises), chronic myeloid leukemia, and other myeloproliferative disorders.
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The lowest verified cash price for Hydrea 500 mg is $8.24 at Mark Cuban Cost Plus, based on 4 verified pharmacy prices checked August 23, 2026.
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How much does Hydrea cost without insurance?
The lowest verified cash price for Hydrea 500 mg is $8.24 at Mark Cuban Cost Plus, based on 4 verified pharmacy prices checked August 23, 2026. Across 4 verified pharmacy prices, cash costs range from $8.24 to $72.99. These are cash prices, no insurance or signup is required, and for many generics the cash price beats a typical insurance copay. Prices vary by pharmacy, location, quantity, and eligibility; confirm the final price at the counter.
About Hydrea
Hydrea is a brand of Hydroxyurea, a blood disorders / oncology medication supplied as capsule in a 500 mg strength. It is commonly used for sickle cell disease (reduces painful crises), chronic myeloid leukemia, and other myeloproliferative disorders.
Ways to save on Hydrea
Cash prices for Hydrea vary by pharmacy, location, quantity, and eligibility, so comparing a few pharmacies and checking whether a discount card beats your copay are the main ways to save. See the live prices above before you fill.
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Clinical information
Typical dosing
Dosing is weight-based and individualized by your prescriber, then adjusted based on regular blood counts. Never change your dose without medical guidance.
Side effects
Boxed warning: can cause severe bone marrow suppression (low blood cell counts), increasing infection and bleeding risk. Requires regular CBC (complete blood count) monitoring, typically every 2-4 weeks initially, then monthly once stable, to catch this early. Also associated with increased long-term skin cancer risk, use sun protection. Common: nausea, mouth sores, temporary hair thinning.
Interactions to know
Use with other bone-marrow-suppressing drugs or radiation can compound blood count drops. Live vaccines should generally be avoided during treatment, discuss with your prescriber.
Pregnancy & breastfeeding
Can cause fetal harm; not recommended during pregnancy. Effective contraception is advised during treatment for people who can become pregnant, and hydroxyurea should be stopped before planned pregnancy per your prescriber's guidance.
Clinical content reviewed by the BetterBuyRx clinical team. Read the full wiki entry and sources →
Frequently asked questions
How much does Hydrea cost without insurance?
The lowest verified cash price for Hydrea 500 mg is $8.24 at Mark Cuban Cost Plus, based on 4 verified pharmacy prices checked August 23, 2026. These are cash prices, no insurance or signup needed, and refresh at least every 72 hours.
Is generic Hydroxyurea the same as Hydrea?
Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.
How much can I save by choosing the generic?
Currently no FDA-approved generic equivalent exists for Hydrea, so the brand and generic prices are similar.
Do I need insurance to get this price?
No. The prices shown on BetterBuyRx are cash prices. Often these beat insurance copays for generics.
How often is this price updated?
At minimum every 72 hours. Many sources refresh every few hours.
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Important safety information
Information for general comparison only. Not medical advice. Confirm with your pharmacist.