How much does Esomeprazole cost without insurance?

As of the latest check, the lowest verified cash price we've found for Esomeprazole is $6.16 at Mark Cuban Cost Plus, across 5 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.

Is there a generic for Esomeprazole?

Yes. Esomeprazole is the generic; it is also sold under brand names such as Nexium 24HR. The generic is typically far cheaper than brand and is what our verified cash prices reflect.

Can I use the free BetterBuyRx discount card for Esomeprazole?

Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Esomeprazole, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.

Why does the price of Esomeprazole vary so much between pharmacies?

U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the PPIs class). That's why comparing verified prices before you fill can save money.

PPIsGeneric available

Esomeprazole

Sold as Nexium 24HR

Esomeprazole (sold as Nexium 24HR) is used for: Acid reducer, GERD.

Compare prices →~$11.20 / mo (generic, NADAC)

As of August 2026, Esomeprazole (20 mg) cash prices on BetterBuyRx start at $6.16 across 5 verified sources (lowest at Mark Cuban Cost Plus). The free BetterBuyRx discount card is compared live on the drug page when a partner network prices this combo. Prices change; confirm at the counter.

Live price snapshot

Source	Type	Cash price
Mark Cuban Cost Plus	pharmacy	$6.16
Mark Cuban Cost Plus	pharmacy	$8.40
Costco Pharmacy	pharmacy	$9.99
Honeybee Health	pharmacy	$17.00
HealthWarehouse	pharmacy	$30.60

See all prices for Esomeprazole →Prices checked Aug 23, 2026

Save with the free BetterBuyRx card

The BetterBuyRx discount card is free, no signup, no insurance needed. When a partner network prices Esomeprazole, the card price appears live on the drug page with its BIN, PCN, Group, and Member ID. Show the card at the pharmacy counter; it can't be combined with insurance.

Get the free card →Esomeprazole coupon & card price →

Frequently asked questions

How much does Esomeprazole cost without insurance?: As of the latest check, the lowest verified cash price we've found for Esomeprazole is $6.16 at Mark Cuban Cost Plus, across 5 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.
Is there a generic for Esomeprazole?: Yes. Esomeprazole is the generic; it is also sold under brand names such as Nexium 24HR. The generic is typically far cheaper than brand and is what our verified cash prices reflect.
Can I use the free BetterBuyRx discount card for Esomeprazole?: Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Esomeprazole, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.
Why does the price of Esomeprazole vary so much between pharmacies?: U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the PPIs class). That's why comparing verified prices before you fill can save money.

Related drugs in this class

We're still expanding this entry. For full prescribing information, see the FDA label below.

Clinical content reviewed by the BetterBuyRx clinical team.

Educational only. Not medical advice. Always confirm with your prescriber or pharmacist.