Omeprazole
Sold as Prilosec
Omeprazole reduces stomach acid. Used for heartburn, GERD, and ulcers. Available OTC and Rx.
As of August 2026, Omeprazole (20 mg) cash prices on BetterBuyRx start at $4.50 across 20 verified sources (lowest at Costco Pharmacy). The free BetterBuyRx discount card recently showed $15.63 in the 750xx ZIP area (checked Aug 21, 2026); card prices vary by ZIP, so enter yours on the drug page for local pharmacy prices. Prices change; confirm at the counter.
What it treats
GERD, peptic ulcer disease, H. pylori eradication (with antibiotics), erosive esophagitis.
Typical dosing
OTC: 20 mg once daily for up to 14 days. Rx doses vary by indication, typically 20-40 mg/day.
Side effects
Common: headache, stomach pain, gas, diarrhea. Long-term use: low magnesium, B12 deficiency, slightly increased fracture risk.
Interactions to know
Reduces effectiveness of clopidogrel (Plavix). Affects absorption of certain HIV and antifungal meds.
Pregnancy & breastfeeding
Generally considered low-risk in pregnancy.
Live price snapshot
| Source | Type | Cash price |
|---|---|---|
| Costco Pharmacy | pharmacy | $4.50 |
| Costco Pharmacy | pharmacy | $4.50 |
| Amazon Pharmacy RxPass | program | $5.00 |
| Blink Health | pharmacy | $5.00 |
| Amazon Pharmacy RxPass | program | $5.00 |
| BetterBuy Rx | coupon | $7.12 |
Save with the free BetterBuyRx card
The BetterBuyRx discount card is free, no signup, no insurance needed. It recently showed $15.63 for Omeprazole at a partner-network pharmacy in the 750xx ZIP area, card prices vary by ZIP, so enter yours on the drug page for local pharmacy prices. Show the card at the pharmacy counter; it can't be combined with insurance.
Frequently asked questions
- How much does Omeprazole cost without insurance?
- As of the latest check, the lowest verified cash price we've found for Omeprazole is $4.50 at Costco Pharmacy, across 20 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.
- Is there a generic for Omeprazole?
- Yes. Omeprazole is the generic; it is also sold under brand names such as Prilosec. The generic is typically far cheaper than brand and is what our verified cash prices reflect.
- Can I use the free BetterBuyRx discount card for Omeprazole?
- Yes. The free BetterBuyRx discount card recently showed $15.63 for this medication at a partner-network pharmacy in the 750xx ZIP area (checked Aug 21, 2026). Card prices vary by ZIP, enter yours on the drug page to see local pharmacy prices. Show the card (BIN, PCN, Group, and Member ID where required) at the counter; it can't be combined with insurance.
- Why does the price of Omeprazole vary so much between pharmacies?
- U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the Proton pump inhibitor (PPI) class). That's why comparing verified prices before you fill can save money.
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Clinical content reviewed by the BetterBuyRx clinical team.
Educational only. Not medical advice. Always confirm with your prescriber or pharmacist.