Fluoxetine
Sold as Prozac
Fluoxetine is an SSRI with a long half-life, useful when discontinuation symptoms are a concern.
As of August 2026, Fluoxetine (20 mg) cash prices on BetterBuyRx start at $4.00 across 8 verified sources (lowest at H-E-B Pharmacy). The free BetterBuyRx discount card is compared live on the drug page when a partner network prices this combo. Prices change; confirm at the counter.
What it treats
Depression, OCD, bulimia, panic disorder, PMDD.
Typical dosing
Typical adult dose: 20 mg once daily, range 20-80 mg.
Side effects
Insomnia, jitteriness, sexual side effects, GI upset.
Interactions to know
Do not combine with MAOIs. Strong CYP2D6 inhibitor, affects many other meds.
Pregnancy & breastfeeding
Risk-benefit discussion.
Live price snapshot
| Source | Type | Cash price |
|---|---|---|
| H-E-B Pharmacy | program | $4.00 |
| Mark Cuban Cost Plus | pharmacy | $5.45 |
| Honeybee Health | pharmacy | $6.50 |
| Costco Pharmacy | pharmacy | $6.99 |
| BetterBuy Rx | coupon | $7.05 |
| Walmart $4/$10 generic list | program | $9.00 |
Save with the free BetterBuyRx card
The BetterBuyRx discount card is free, no signup, no insurance needed. When a partner network prices Fluoxetine, the card price appears live on the drug page with its BIN, PCN, Group, and Member ID. Show the card at the pharmacy counter; it can't be combined with insurance.
Frequently asked questions
- How much does Fluoxetine cost without insurance?
- As of the latest check, the lowest verified cash price we've found for Fluoxetine is $4.00 at H-E-B Pharmacy, across 8 verified sources. Cash prices are unregulated and vary by pharmacy, so compare before you fill and confirm the price at the counter.
- Is there a generic for Fluoxetine?
- Yes. Fluoxetine is the generic; it is also sold under brand names such as Prozac. The generic is typically far cheaper than brand and is what our verified cash prices reflect.
- Can I use the free BetterBuyRx discount card for Fluoxetine?
- Yes. The free BetterBuyRx discount card is compared live on the drug page and, when a partner network prices Fluoxetine, shows the card price with its BIN, PCN, Group, and Member ID. It can't be combined with insurance.
- Why does the price of Fluoxetine vary so much between pharmacies?
- U.S. cash prescription prices are unregulated, each pharmacy sets its own markup, and discount programs and mail-order sources widen the spread further (this is common across the SSRI antidepressant class). That's why comparing verified prices before you fill can save money.
Related drugs in this class
Clinical content reviewed by the BetterBuyRx clinical team.
Educational only. Not medical advice. Always confirm with your prescriber or pharmacist.