Digestive Health Medications: Comparing Costs and Ways to Save
Gastrointestinal medications cover a broad range, from acid-reflux drugs to treatments for chronic digestive conditions. Many common ones are available as generics — several even have over-the-counter versions — while specialty GI drugs can be far more expensive.
For the generic and OTC options, comparing prices and checking whether a discount card beats the shelf or copay price is usually enough. For higher-cost branded GI drugs, manufacturer programs may help eligible patients. Each medication below links to a page with current pricing so you can compare.
Digestive Health medications (50)
Each medication links to its own page with live cash and discount prices. Prices vary by pharmacy, location, quantity, and eligibility.
- LotronexSave 100%
Alosetron · 1mg
Live prices on detail page
- MytesiSave 100%
Crofelemer · 125mg
Live prices on detail page
- GimotiSave 100%
Metoclopramide Nasal · 15mg
Live prices on detail page
- DipentumSave 100%
Olsalazine · 250mg
Live prices on detail page
- RelistorSave 100%
Methylnaltrexone · 150mg
Live prices on detail page
- ViberziSave 100%
Eluxadoline · 100mg
Live prices on detail page
- ColazalSave 79%
Balsalazide · 750mg
from $355.65
- TrulanceSave 100%
Plecanatide · 3mg
Live prices on detail page
- SymproicSave 100%
Naldemedine · 0.2mg
Live prices on detail page
- MotegritySave 86%
Prucalopride · 2mg
from $73.97
- MovantikSave 100%
Naloxegol · 25mg
Live prices on detail page
- ZofranSave 98%
Ondansetron · 4 mg
from $7.20
- AciphexSave 94%
Rabeprazole · 20 mg
from $12.00
- LialdaSave 66%
Mesalamine Lialda · 1.2g
from $91.16
- ProtonixSave 96%
Pantoprazole · 40 mg
from $5.40
- Amitiza 24Save 100%
Lubiprostone 24 · 24mcg
Live prices on detail page
- BentylSave 86%
Dicyclomine · 20 mg
from $12.00
- Nexium 24HRSave 60%
Esomeprazole · 20 mg
from $11.20
- MiraLAXSave 63%
Polyethylene Glycol · 17 g
from $9.20
- Prilosec OTCSave 62%
Omeprazole · 20 mg
from $9.50
- Pepcid ACSave 65%
Famotidine · 20 mg
from $5.90
- Preparation HSave 50%
Phenylephrine/Hydrocortisone · -
from $7.99
- DulcolaxSave 62%
Bisacodyl · 5 mg
from $4.50
- ImodiumSave 65%
Loperamide · 2 mg
from $3.80
- Actigall
Ursodiol · 300 mg
Live prices on detail page
- Amitiza
Lubiprostone · 24 mcg
Live prices on detail page
- Apriso
Mesalamine Apriso · 0.375g
from $489.52
- Axid
Nizatidine · 150 mg
Live prices on detail page
- Azulfidine
Sulfasalazine · 500 mg
Live prices on detail page
- Carafate Suspension
Sucralfate Suspension · 1g/10mL
Live prices on detail page
- Creon
Pancrelipase · 24000 units
Live prices on detail page
- Cytotec
Misoprostol · 200 mcg
Live prices on detail page
- Delzicol
Mesalamine Delzicol · 400mg
from $653.49
- Dexilant
Dexlansoprazole · 60 mg
Live prices on detail page
- Dramamine
Dimenhydrinate · 50 mg
Live prices on detail page
- Imodium Multi-Symptom
Loperamide/Simethicone · 2mg/125mg
Live prices on detail page
- Levsin
Hyoscyamine · 0.125 mg
Live prices on detail page
- Lotronex 1mg
Alosetron 1mg · 1mg
Live prices on detail page
- Pentasa
Mesalamine Pentasa · 500mg
from $603.97
- Prevacid
Lansoprazole · 30 mg
Live prices on detail page
- Sancuso
Granisetron · 1 mg
Live prices on detail page
- Tagamet
Cimetidine · 400 mg
Live prices on detail page
- Transderm Scop
Scopolamine · 1.5 mg
Live prices on detail page
- Uceris
Budesonide Uceris · 9mg
from $1259.07
- Uceris Rectal
Budesonide Rectal · 2mg
Live prices on detail page
- Xifaxan
Rifaximin · 550 mg
Live prices on detail page
- Zelnorm
Tegaserod · 6mg
Live prices on detail page
- Pepto-Bismol
Bismuth Subsalicylate · 262mg
from $8.69
- Cytotec Vaginal
Misoprostol Vaginal · 200mcg
from $48.36
- Motegrity 2mg
Prucalopride HighDose · 2mg
from $73.97
Frequently asked questions
Why do prices for the same medication vary so much between pharmacies?
Cash prices are set by each pharmacy, not by a single national list, so the same drug and quantity can cost very different amounts across the street from each other. Discount-card prices, manufacturer arrangements, and a pharmacy's own contracts all move the final number. Comparing a few pharmacies before you fill is the simplest way to avoid overpaying.
Is the over-the-counter version cheaper than the prescription?
Sometimes. A few GI medications are sold both by prescription and over the counter, and the cash price can differ between the two. Which is right for you depends on the strength and your situation — ask your pharmacist. This page compares cost, not clinical suitability.
Could a generic version lower my cost?
When an FDA-approved generic exists, it usually costs far less than the brand while containing the same active ingredient. Whether a generic is appropriate for you is a clinical decision — ask your doctor or pharmacist. This page is about cost comparison only, not which medication you should take.
Related savings guides
- Generic vs Brand-Name Medications: Cost Differences Explained
How generic and brand-name medications differ in cost and FDA approval, with data on typical savings and what to ask your pharmacist.
- The Best Ways to Find Cheap Medicine, Ranked by Effort
A practical, ranked breakdown of ways to find cheaper medication, from a two-minute price check to longer-term assistance program applications.
- How to Compare Prescription Prices Near You
A step-by-step guide to comparing prescription drug prices at pharmacies near you, including what info to gather and questions to ask.
This page is for cost and savings education only. It is not medical advice and makes no claims about which medication is right for you or how well any drug works. Talk to your doctor or pharmacist about your specific medications and coverage. Prices vary by pharmacy, location, quantity, and eligibility.
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