How much does Humulin R U-500 cost without insurance?

Live cash prices for Humulin R U-500 500 units/mL are verified within the last 72 hours — see the table above for the current cheapest source.

What pharmacy has the cheapest Humulin R U-500?

Cost Plus Drugs and Costco typically have the lowest cash price for generic Insulin Regular U-500. CVS and Walgreens are the most expensive. Exact rankings update live above.

Which pharmacy has the cheapest Humulin R U-500 in 2026?

GoodRx coupon currently has the lowest verified cash price for Humulin R U-500 (Insulin Regular U-500) at $0.00. Cost Plus Drugs and Costco are consistently the cheapest US pharmacies for most generics.

Is CVS or Walgreens cheaper for Humulin R U-500?

Neither — both are typically 30–60% more expensive than Cost Plus or Costco. CVS and Walgreens consistently rank as the most expensive cash-pay pharmacies for Insulin Regular U-500.

How often do these prices change?

BetterBuyRx refreshes prices at minimum every 72 hours from public retail price feeds. Mail-order partners like Cost Plus and Amazon Pharmacy can change daily.

Diabetes

Humulin R U-500

Name: Humulin R U-500 500 units/mL (Insulin Regular U-500)
Brand: Humulin R U-500
SKU: humulin-r-u-500
Availability: InStock

Insulin Regular U-500 · 500 units/mL · injection · qty 1

Type 2 diabetes blood-sugar control.

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Live verified prices

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Common uses & information

Humulin R U-500 is a brand of Insulin Regular U-500, a diabetes medication supplied as injection in a 500 units/mL strength. It is commonly used for type 2 diabetes blood-sugar control.

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Price summary

Form	Class	Brand avg	Generic avg	Savings
injection 500 units/mL	Rx	$2123.12	see live prices above	—

Clinical information

Clinical content reviewed by the BetterBuyRx clinical team. Read the full wiki entry and sources →

Manufacturer & patient assistance programs

Lilly Insulins Value Program
Available to anyone with a valid prescription, insured or not — no income requirement.
$35/monthEnroll →

FAQ

Is generic Insulin Regular U-500 the same as Humulin R U-500?

Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.

How much can I save by choosing the generic?

Currently no FDA-approved generic equivalent exists for Humulin R U-500, so the brand and generic prices are similar.

Do I need insurance to get this price?

No. The prices shown on BetterBuyRx are cash prices. Often these beat insurance copays for generics.

How often is this price updated?

At minimum every 72 hours. Many sources refresh every few hours.

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See generic Insulin Regular U-500 prices →

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Information for general comparison only. Not medical advice. Confirm with your pharmacist.