How much does Tysabri cost without insurance?

Live cash prices for Tysabri 300mg/15mL are verified within the last 72 hours — see the table above for the current cheapest source.

What pharmacy has the cheapest Tysabri?

Cost Plus Drugs and Costco typically have the lowest cash price for generic Natalizumab. CVS and Walgreens are the most expensive. Exact rankings update live above.

How much does Tysabri cost without insurance?

Tysabri (Natalizumab) 300mg/15mL cash price averages $0.00 for the generic and $8313.86 for the brand. Cost Plus and Costco usually have the lowest verified cash prices.

Is it cheaper to pay cash than use insurance for Tysabri?

For generics, the cash price (especially at Cost Plus, Amazon Pharmacy, Costco) is often lower than a typical insurance copay. You're allowed to skip insurance on any fill.

Can I buy Tysabri without a prescription?

No — Tysabri requires a prescription from a licensed prescriber. Telehealth services can issue one quickly when appropriate.

Biologic

Tysabri

Name: Tysabri 300mg/15mL (Natalizumab)
Brand: Tysabri
SKU: tysabri
Availability: InStock

Natalizumab · 300mg/15mL · injection · qty 1

Specialty biologic — autoimmune / immunology.

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Common uses & information

Tysabri is a brand of Natalizumab, a biologic medication supplied as injection in a 300mg/15mL strength. It is commonly used for specialty biologic — autoimmune / immunology.

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Price summary

Form	Class	Brand avg	Generic avg	Savings
injection 300mg/15mL	Rx	$8313.86	see live prices above	—

Clinical information

Clinical content reviewed by the BetterBuyRx clinical team. Read the full wiki entry and sources →

Manufacturer & patient assistance programs

For patient assistance, check NeedyMeds and RxAssist.

FAQ

Is generic Natalizumab the same as Tysabri?

Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.

How much can I save by choosing the generic?

Currently no FDA-approved generic equivalent exists for Tysabri, so the brand and generic prices are similar.

Do I need insurance to get this price?

No. The prices shown on BetterBuyRx are cash prices. Often these beat insurance copays for generics.

How often is this price updated?

At minimum every 72 hours. Many sources refresh every few hours.

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Information for general comparison only. Not medical advice. Confirm with your pharmacist.