How much does Spravato cost without insurance?

Live cash prices for Spravato 56mg are verified within the last 72 hours — see the table above for the current cheapest source.

What pharmacy has the cheapest Spravato?

Cost Plus Drugs and Costco typically have the lowest cash price for generic Esketamine. CVS and Walgreens are the most expensive. Exact rankings update live above.

Mental Health

Spravato

Name: Spravato 56mg (Esketamine)
Brand: Spravato
SKU: spravato
Availability: InStock

Esketamine · 56mg · spray · qty 1

Depression, anxiety, or mood disorders.

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Common uses & information

Spravato is a brand of Esketamine, a mental health medication supplied as spray in a 56mg strength. It is commonly used for depression, anxiety, or mood disorders.

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Price summary

Form	Class	Brand avg	Generic avg	Savings
spray 56mg	Rx	$1515.65	see live prices above	—

Clinical information

Clinical content reviewed by the BetterBuyRx clinical team. Read the full wiki entry and sources →

Manufacturer & patient assistance programs

For patient assistance, check NeedyMeds and RxAssist.

FAQ

Is generic Esketamine the same as Spravato?

Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.

How much can I save by choosing the generic?

Currently no FDA-approved generic equivalent exists for Spravato, so the brand and generic prices are similar.

Do I need insurance to get this price?

No. The prices shown on BetterBuyRx are cash prices. Often these beat insurance copays for generics.

How often is this price updated?

At minimum every 72 hours. Many sources refresh every few hours.

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Information for general comparison only. Not medical advice. Confirm with your pharmacist.