Zoloft
Generic Sertraline · tablet · Rx required · Depression, anxiety, OCD, PTSD.
Fetching live prices…
The lowest verified cash price for Zoloft 50 mg is $5.00 at Amazon Pharmacy RxPass, based on 6 verified pharmacy prices checked August 26, 2026.
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How much does Zoloft cost without insurance?
The lowest verified cash price for Zoloft 50 mg is $5.00 at Amazon Pharmacy RxPass, based on 6 verified pharmacy prices checked August 26, 2026. Across 6 verified pharmacy prices, cash costs range from $5.00 to $43.99. These are cash prices, no insurance or signup is required, and for many generics the cash price beats a typical insurance copay. Prices vary by pharmacy, location, quantity, and eligibility; confirm the final price at the counter.
Zoloft is commonly dispensed as tablet in 25mg, 50mg, 100mg strengths. Price varies by strength, quantity, and pharmacy, set your strength and quantity above to see the cash price for your exact fill.
About Zoloft
Zoloft is a brand of Sertraline, a mental health medication supplied as tablet in a 50 mg strength. It is commonly used for depression, anxiety, OCD, PTSD.
An FDA-approved generic (Sertraline) is available and typically costs less than the brand, compare both cash prices in the results above before you fill.
Ways to save on Zoloft
Choosing the generic (Sertraline) instead of the brand can lower your cost, on average about $172.80 per fill (97% off the brand price) in our catalog, though the exact price varies by pharmacy, location, quantity, and eligibility. Compare the live cash and discount prices above, and ask about a 90-day supply if you take it long-term.
Related savings guides
Clinical information
Typical dosing
Typical adult starting dose: 50 mg once daily; range 50-200 mg/day.
Side effects
Common: nausea, diarrhea, insomnia, sexual side effects, sweating. Serious (rare): serotonin syndrome, abnormal bleeding, activation of mania in bipolar disorder.
Interactions to know
⚠️ MAOI washout: Do NOT use sertraline within 14 days of stopping an MAOI (e.g. phenelzine, tranylcypromine, selegiline, linezolid, IV methylene blue), and do not start an MAOI within 14 days of stopping sertraline. Combining them can cause serotonin syndrome, which can be fatal. Caution with NSAIDs and blood thinners (bleeding risk), and with other serotonergic drugs (triptans, tramadol, other antidepressants).
Pregnancy & breastfeeding
Discuss with prescriber, risk-benefit decision.
Clinical content reviewed by the BetterBuyRx clinical team, on 2026-07-07. Read the full wiki entry and sources →
Frequently asked questions
How much does Zoloft cost without insurance?
The lowest verified cash price for Zoloft 50 mg is $5.00 at Amazon Pharmacy RxPass, based on 6 verified pharmacy prices checked August 26, 2026. These are cash prices, no insurance or signup needed, and refresh at least every 72 hours.
Is generic Sertraline the same as Zoloft?
Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.
How much can I save by choosing the generic?
On average $172.80 per fill (97% off the brand price). Savings vary by pharmacy, see live prices above.
Do I need insurance to get this price?
No. The prices shown on BetterBuyRx are cash prices. Often these beat insurance copays for generics.
How often is this price updated?
At minimum every 72 hours. Many sources refresh every few hours.
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Important safety information
Boxed warning
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults (up to age 24), especially in the first weeks of treatment or after a dose change. Monitor closely for worsening mood or new suicidal thoughts.
Information for general comparison only. Not medical advice. Confirm with your pharmacist.