Acid Reflux & GERD medication prices (2026)
Proton pump inhibitors (omeprazole, pantoprazole, esomeprazole) and H2 blockers (famotidine) treat GERD and frequent heartburn. Most are generic and available OTC or by prescription for under $10/month.
All Acid reflux medications ranked by cash price
| Brand | Generic | Strength | Generic cash | Brand cash |
|---|---|---|---|---|
| Prevacid | Lansoprazole | 30 mg | see live | see live |
| Dexilant | Dexlansoprazole | 60 mg | see live | see live |
| Tagamet | Cimetidine | 400 mg | see live | see live |
| Axid | Nizatidine | 150 mg | see live | see live |
| Cytotec | Misoprostol | 200 mcg | see live | see live |
| Levsin | Hyoscyamine | 0.125 mg | see live | see live |
| Amitiza | Lubiprostone | 24 mcg | see live | see live |
| Xifaxan | Rifaximin | 550 mg | see live | see live |
| Creon | Pancrelipase | 24000 units | see live | see live |
| Actigall | Ursodiol | 300 mg | see live | see live |
| Azulfidine | Sulfasalazine | 500 mg | see live | see live |
| Transderm Scop | Scopolamine | 1.5 mg | see live | see live |
| Dramamine | Dimenhydrinate | 50 mg | see live | see live |
| Sancuso | Granisetron | 1 mg | see live | see live |
| Amitiza 24 | Lubiprostone 24 | 24mcg | see live | $100.07 |
| Carafate Suspension | Sucralfate Suspension | 1g/10mL | see live | see live |
| Dipentum | Olsalazine | 250mg | see live | $1745.66 |
| Gimoti | Metoclopramide Nasal | 15mg | see live | $2115.79 |
| Imodium Multi-Symptom | Loperamide/Simethicone | 2mg/125mg | see live | see live |
| Lotronex | Alosetron | 1mg | see live | $3974.68 |
| Lotronex 1mg | Alosetron 1mg | 1mg | see live | see live |
| Movantik | Naloxegol | 25mg | see live | $405.09 |
| Mytesi | Crofelemer | 125mg | see live | $2490.10 |
| Relistor | Methylnaltrexone | 150mg | see live | $1579.99 |
| Symproic | Naldemedine | 0.2mg | see live | $450.22 |
| Trulance | Plecanatide | 3mg | see live | $543.23 |
| Uceris Rectal | Budesonide Rectal | 2mg | see live | see live |
| Viberzi | Eluxadoline | 100mg | see live | $1570.54 |
| Zelnorm | Tegaserod | 6mg | see live | see live |
| Imodium | Loperamide | 2 mg | $3.80 | $10.99 |
| Dulcolax | Bisacodyl | 5 mg | $4.50 | $11.99 |
| Protonix | Pantoprazole | 40 mg | $5.40 | $148.00 |
| Pepcid AC | Famotidine | 20 mg | $5.90 | $16.99 |
| Zofran | Ondansetron | 4 mg | $7.20 | $312.00 |
| Preparation H | Phenylephrine/Hydrocortisone | - | $7.99 | $15.99 |
| Pepto-Bismol | Bismuth Subsalicylate | 262mg | $8.69 | see live |
| MiraLAX | Polyethylene Glycol | 17 g | $9.20 | $24.99 |
| Prilosec OTC | Omeprazole | 20 mg | $9.50 | $24.99 |
| Nexium 24HR | Esomeprazole | 20 mg | $11.20 | $27.99 |
| Aciphex | Rabeprazole | 20 mg | $12.00 | $218.00 |
| Cytotec Vaginal | Misoprostol Vaginal | 200mcg | $48.36 | see live |
| Motegrity | Prucalopride | 2mg | $73.97 | $522.92 |
| Motegrity 2mg | Prucalopride HighDose | 2mg | $73.97 | see live |
| Lialda | Mesalamine Lialda | 1.2g | $91.16 | $267.86 |
| Colazal | Balsalazide | 750mg | $355.65 | $1699.08 |
| Apriso | Mesalamine Apriso | 0.375g | $489.52 | $489.52 |
| Pentasa | Mesalamine Pentasa | 500mg | $603.97 | $603.97 |
| Delzicol | Mesalamine Delzicol | 400mg | $653.49 | $653.49 |
| Uceris | Budesonide Uceris | 9mg | $1259.07 | $1259.07 |
FAQ
What is the cheapest medication for Acid reflux?
Generic Lansoprazole (Prevacid) averages $0.00 cash. Cost Plus and Costco usually have the lowest verified prices.
Can I fill Acid reflux medications without insurance?
Yes. Every drug on this page can be filled cash-pay at any US pharmacy. Generic versions are usually under $15/month at Cost Plus, Costco, or with a GoodRx coupon.
Are generic Acid reflux drugs as good as brand?
Yes — the FDA requires generics to contain the same active ingredient at the same strength as the brand and to be therapeutically equivalent.