Acid Reflux & GERD medication prices (2026)
Proton pump inhibitors (omeprazole, pantoprazole, esomeprazole) and H2 blockers (famotidine) treat GERD and frequent heartburn. Most are generic and available OTC or by prescription for under $10/month.
All Acid reflux medications ranked by cash price
| Brand | Generic | Strength | Generic cash | Brand cash |
|---|---|---|---|---|
| Prevacid | Lansoprazole | 30 mg | see live | see live |
| Dexilant | Dexlansoprazole | 60 mg | see live | see live |
| Tagamet | Cimetidine | 400 mg | see live | see live |
| Axid | Nizatidine | 150 mg | see live | see live |
| Cytotec | Misoprostol | 200 mcg | see live | see live |
| Levsin | Hyoscyamine | 0.125 mg | see live | see live |
| Amitiza | Lubiprostone | 24 mcg | see live | see live |
| Xifaxan | Rifaximin | 550 mg | see live | see live |
| Creon | Pancrelipase | 24000 units | see live | see live |
| Actigall | Ursodiol | 300 mg | see live | see live |
| Azulfidine | Sulfasalazine | 500 mg | see live | see live |
| Transderm Scop | Scopolamine | 1.5 mg | see live | see live |
| Dramamine | Dimenhydrinate | 50 mg | see live | see live |
| Sancuso | Granisetron | 1 mg | see live | see live |
| Amitiza 24 | Lubiprostone 24 | 24mcg | see live | $100.07 |
| Carafate Suspension | Sucralfate Suspension | 1g/10mL | see live | see live |
| Dipentum | Olsalazine | 250mg | see live | $1745.66 |
| Gimoti | Metoclopramide Nasal | 15mg | see live | $2115.79 |
| Imodium Multi-Symptom | Loperamide/Simethicone | 2mg/125mg | see live | see live |
| Lotronex | Alosetron | 1mg | see live | $3974.68 |
| Lotronex 1mg | Alosetron 1mg | 1mg | see live | see live |
| Movantik | Naloxegol | 25mg | see live | $405.09 |
| Mytesi | Crofelemer | 125mg | see live | $2490.10 |
| Relistor | Methylnaltrexone | 150mg | see live | $1579.99 |
| Symproic | Naldemedine | 0.2mg | see live | $450.22 |
| Trulance | Plecanatide | 3mg | see live | $543.23 |
| Uceris Rectal | Budesonide Rectal | 2mg | see live | see live |
| Viberzi | Eluxadoline | 100mg | see live | $1570.54 |
| Zelnorm | Tegaserod | 6mg | see live | see live |
| Imodium | Loperamide | 2 mg | $3.80 | $10.99 |
| Dulcolax | Bisacodyl | 5 mg | $4.50 | $11.99 |
| Protonix | Pantoprazole | 40 mg | $5.40 | $148.00 |
| Pepcid AC | Famotidine | 20 mg | $5.90 | $16.99 |
| Zofran | Ondansetron | 4 mg | $7.20 | $312.00 |
| Preparation H | Phenylephrine/Hydrocortisone | - | $7.99 | $15.99 |
| Pepto-Bismol | Bismuth Subsalicylate | 262mg | $8.69 | see live |
| MiraLAX | Polyethylene Glycol | 17 g | $9.20 | $24.99 |
| Prilosec OTC | Omeprazole | 20 mg | $9.50 | $24.99 |
| Nexium 24HR | Esomeprazole | 20 mg | $11.20 | $27.99 |
| Bentyl | Dicyclomine | 20 mg | $12.00 | $84.00 |
| Aciphex | Rabeprazole | 20 mg | $12.00 | $218.00 |
| Cytotec Vaginal | Misoprostol Vaginal | 200mcg | $48.36 | see live |
| Motegrity | Prucalopride | 2mg | $73.97 | $522.92 |
| Motegrity 2mg | Prucalopride HighDose | 2mg | $73.97 | see live |
| Lialda | Mesalamine Lialda | 1.2g | $91.16 | $267.86 |
| Colazal | Balsalazide | 750mg | $355.65 | $1699.08 |
| Apriso | Mesalamine Apriso | 0.375g | $489.52 | $489.52 |
| Pentasa | Mesalamine Pentasa | 500mg | $603.97 | $603.97 |
| Delzicol | Mesalamine Delzicol | 400mg | $653.49 | $653.49 |
| Uceris | Budesonide Uceris | 9mg | $1259.07 | $1259.07 |
FAQ
What is the cheapest medication for Acid reflux?
Generic Lansoprazole (Prevacid) averages $0.00 cash. Cost Plus and Costco usually have the lowest verified prices.
Can I fill Acid reflux medications without insurance?
Yes. Every drug on this page can be filled cash-pay at any US pharmacy. Generic versions are usually under $15/month at Cost Plus, Costco, or with a GoodRx coupon.
Are generic Acid reflux drugs as good as brand?
Yes, the FDA requires generics to contain the same active ingredient at the same strength as the brand and to be therapeutically equivalent.