Weight Loss & Obesity medication prices (2026)
FDA-approved weight-loss drugs include GLP-1 agonists (semaglutide as Wegovy, tirzepatide as Zepbound), phentermine, and orlistat. Brand GLP-1s are the most-asked-about prescriptions in the US in 2026 and routinely cost $1,000+/month without insurance.
All Weight loss medications ranked by cash price
| Brand | Generic | Strength | Generic cash | Brand cash |
|---|---|---|---|---|
| Byetta | Exenatide | 10 mcg/dose | see live | see live |
| Ozempic | Semaglutide | 1 mg/dose | $920.00 | $968.00 |
| Zepbound | Tirzepatide | 5 mg/dose | $1010.00 | $1059.00 |
| Mounjaro | Tirzepatide | 5 mg/dose | $1020.00 | $1069.00 |
| Wegovy | Semaglutide | 2.4 mg/dose | $1300.00 | $1349.00 |
FAQ
What is the cheapest medication for Weight loss?
Generic Exenatide (Byetta) averages $0.00 cash. Cost Plus and Costco usually have the lowest verified prices.
Can I fill Weight loss medications without insurance?
Yes. Every drug on this page can be filled cash-pay at any US pharmacy. Generic versions are usually under $15/month at Cost Plus, Costco, or with a GoodRx coupon.
Are generic Weight loss drugs as good as brand?
Yes, the FDA requires generics to contain the same active ingredient at the same strength as the brand and to be therapeutically equivalent.