Pain medication prices (2026)
Over-the-counter NSAIDs (ibuprofen, naproxen) and acetaminophen handle most mild-to-moderate pain. Prescription NSAIDs (meloxicam, diclofenac, celecoxib) and muscle relaxants are common at retail. Opioids are controlled and require special handling.
All Pain medications ranked by cash price
| Brand | Generic | Strength | Generic cash | Brand cash |
|---|---|---|---|---|
| Soma | Carisoprodol | 350 mg | see live | see live |
| Skelaxin | Metaxalone | 800 mg | see live | see live |
| Duragesic | Fentanyl | 25 mcg/hr | see live | see live |
| Dilaudid | Hydromorphone | 4 mg | see live | see live |
| Dolophine | Methadone | 10 mg | see live | see live |
| Nucynta | Tapentadol | 50 mg | see live | see live |
| Fioricet | Butalbital/Acetaminophen/Caffeine | 50/300/40 mg | see live | see live |
| Belbuca | Buprenorphine Buccal | 150mcg | see live | $735.76 |
| Demerol | Meperidine | 50mg | see live | $221.30 |
| Nubain | Nalbuphine | 10mg/mL | see live | $307.15 |
| Nucynta ER | Tapentadol ER | 100mg | see live | $1244.53 |
| Stadol | Butorphanol | 1mg/mL | see live | $83.57 |
| Bayer Aspirin | Aspirin | 325 mg | $2.20 | see live |
| Percocet | Acetaminophen/Oxycodone | 325/10 mg | $2.74 | $1016.86 |
| Bayer Aspirin | Aspirin | 325 mg | $3.20 | $9.99 |
| Advil | Ibuprofen | 200 mg | $3.99 | $12.99 |
| Tylenol | Acetaminophen | 500 mg | $4.27 | $14.99 |
| Aleve | Naproxen Sodium | 220 mg | $4.50 | $13.49 |
| Mobic | Meloxicam | 15 mg | $5.40 | $112.00 |
| Flexeril | Cyclobenzaprine | 10 mg | $5.40 | $78.00 |
| Methadose | Methadone Oral | 10mg | $6.25 | $6.25 |
| Exalgo | Hydromorphone ER | 8mg | $6.53 | $6.53 |
| Naprosyn | Naproxen | 500 mg | $7.40 | $78.00 |
| Ultram | Tramadol | 50 mg | $8.20 | $112.00 |
| Zanaflex | Tizanidine | 4 mg | $8.40 | $112.00 |
| Voltaren | Diclofenac | 75 mg | $9.20 | $98.00 |
| Celebrex | Celecoxib | 200 mg | $12.40 | $312.00 |
| Ultracet | Tramadol/Acetaminophen | 37.5mg/325mg | $13.26 | $13.26 |
| Norco | Hydrocodone/Acetaminophen | 5/325 mg | $18.40 | $182.00 |
| various | Codeine | 30mg | $20.96 | $20.96 |
| OxyContin | Oxycodone | 10 mg | $68.00 | $478.00 |
| MS Contin | Morphine Sulfate ER | 30mg | $80.47 | $480.64 |
| Ultram ER | Tramadol ER | 100mg | $108.53 | $462.53 |
| Opana | Oxymorphone | 10mg | $257.15 | $660.13 |
| Butrans | Buprenorphine Transdermal | 10mcg/hr | $305.86 | $418.87 |
| Levo-Dromoran | Levorphanol | 2mg | $1667.69 | $1667.69 |
FAQ
What is the cheapest medication for Pain?
Generic Carisoprodol (Soma) averages $0.00 cash. Cost Plus and Costco usually have the lowest verified prices.
Can I fill Pain medications without insurance?
Yes. Every drug on this page can be filled cash-pay at any US pharmacy. Generic versions are usually under $15/month at Cost Plus, Costco, or with a GoodRx coupon.
Are generic Pain drugs as good as brand?
Yes — the FDA requires generics to contain the same active ingredient at the same strength as the brand and to be therapeutically equivalent.