Zofran
Generic Ondansetron · tablet · Rx required · Anti-nausea.
Fetching live prices…
The lowest verified cash price for Zofran 4 mg is $5.00 at Amazon Pharmacy RxPass, based on 6 verified pharmacy prices checked August 22, 2026.
Local BetterBuy Rx prices near you
Enter your ZIP to check real pharmacy prices in your area with the free BetterBuy Rx discount card. No ZIP? The national price is in the results above.
How much does Zofran cost without insurance?
The lowest verified cash price for Zofran 4 mg is $5.00 at Amazon Pharmacy RxPass, based on 6 verified pharmacy prices checked August 22, 2026. Across 6 verified pharmacy prices, cash costs range from $5.00 to $76.00. These are cash prices, no insurance or signup is required, and for many generics the cash price beats a typical insurance copay. Prices vary by pharmacy, location, quantity, and eligibility; confirm the final price at the counter.
About Zofran
Zofran is a brand of Ondansetron, a gi medication supplied as tablet in a 4 mg strength. It is commonly used for anti-nausea.
An FDA-approved generic (Ondansetron) is available and typically costs less than the brand, compare both cash prices in the results above before you fill.
Ways to save on Zofran
Choosing the generic (Ondansetron) instead of the brand can lower your cost, on average about $304.80 per fill (98% off the brand price) in our catalog, though the exact price varies by pharmacy, location, quantity, and eligibility. Compare the live cash and discount prices above, and ask about a 90-day supply if you take it long-term.
Related savings guides
Clinical information
Typical dosing
Typical adult dose: 4-8 mg by mouth every 8 hours as needed, or as directed by your prescriber.
Side effects
Common: headache, constipation, tiredness. Serious (rare): QT prolongation (irregular heartbeat), serotonin syndrome when combined with other serotonergic drugs.
Interactions to know
Caution with other drugs that prolong the QT interval, and with other serotonergic medications (e.g. SSRIs, tramadol) due to serotonin syndrome risk.
Pregnancy & breastfeeding
FDA Pregnancy Category B. Widely used off-label for nausea in pregnancy. Some studies suggested a small association with cleft palate in the first trimester; larger studies have not confirmed increased birth defect risk. Discuss with your OB or midwife before use, do not self-prescribe.
Clinical content reviewed by the BetterBuyRx clinical team. Read the full wiki entry and sources →
Frequently asked questions
How much does Zofran cost without insurance?
The lowest verified cash price for Zofran 4 mg is $5.00 at Amazon Pharmacy RxPass, based on 6 verified pharmacy prices checked August 22, 2026. These are cash prices, no insurance or signup needed, and refresh at least every 72 hours.
Is generic Ondansetron the same as Zofran?
Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.
How much can I save by choosing the generic?
On average $304.80 per fill (98% off the brand price). Savings vary by pharmacy, see live prices above.
Do I need insurance to get this price?
No. The prices shown on BetterBuyRx are cash prices. Often these beat insurance copays for generics.
How often is this price updated?
At minimum every 72 hours. Many sources refresh every few hours.
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Important safety information
Information for general comparison only. Not medical advice. Confirm with your pharmacist.