How much does Prilosec OTC cost without insurance?

Prilosec OTC (Omeprazole) 20 mg costs around $9.50 cash for the generic and $24.99 for the brand. Live prices on this page are verified within the last 72 hours.

What pharmacy has the cheapest Prilosec OTC?

Cost Plus Drugs and Costco typically have the lowest cash price for generic Omeprazole. CVS and Walgreens are the most expensive. Exact rankings update live above.

Which pharmacy has the cheapest Prilosec OTC in 2026?

Cost Plus Drugs and Costco are consistently the cheapest US pharmacies for generic Omeprazole.

Is CVS or Walgreens cheaper for Prilosec OTC?

Neither — both are typically 30–60% more expensive than Cost Plus or Costco. CVS and Walgreens consistently rank as the most expensive cash-pay pharmacies for Omeprazole.

How often do these prices change?

BetterBuyRx refreshes prices at minimum every 72 hours from public retail price feeds. Mail-order partners like Cost Plus and Amazon Pharmacy can change daily.

Prilosec OTC

Name: Prilosec OTC 20 mg (Omeprazole)
Brand: Prilosec OTC
SKU: prilosec-otc

Omeprazole · 20 mg · tablet · qty 42

Also available in: 10mg · 20mg · 40mg

Frequent heartburn relief.

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Live verified prices

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Common uses & information

Prilosec OTC is a brand of Omeprazole, a gi medication supplied as tablet in a 20 mg strength. It is commonly used for frequent heartburn relief.

An FDA-approved generic (Omeprazole) is available and typically costs less than the brand — compare both cash prices in the table above before you fill.

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Price summary

Form	Class	Brand avg	Generic avg	Savings
tablet 20 mg	OTC	$24.99 — generic is cheaper, see recommendation	$9.50Generic recommended	62%

Clinical information

Typical dosing

OTC: 20 mg once daily for up to 14 days. Rx doses vary by indication, typically 20–40 mg/day.

Side effects

Common: headache, stomach pain, gas, diarrhea. Long-term use: low magnesium, B12 deficiency, slightly increased fracture risk.

Interactions to know

Reduces effectiveness of clopidogrel (Plavix). Affects absorption of certain HIV and antifungal meds.

Pregnancy & breastfeeding

Generally considered low-risk in pregnancy.

Clinical content reviewed by the BetterBuyRx clinical team. Read the full wiki entry and sources →

Manufacturer & patient assistance programs

For patient assistance, check NeedyMeds and RxAssist.

Other brands of Omeprazole

Same active ingredient, different brand. Compare prices.

Prilosec
20 mg · tablet
from $43.47

FAQ

Is generic Omeprazole the same as Prilosec OTC?

Yes. The FDA requires generics to contain the same active ingredient at the same strength as the brand. Inactive ingredients (binders, dyes) may differ.

How much can I save by choosing the generic?

On average $15.49 per fill (62% off the brand price). Savings vary by pharmacy — see live prices above.

Do I need insurance to get this price?

No. The prices shown on BetterBuyRx are cash prices. Often these beat insurance copays for generics.

How often is this price updated?

At minimum every 72 hours. Many sources refresh every few hours.

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Information for general comparison only. Not medical advice. Confirm with your pharmacist.